多巴胺β羟化酶

多巴胺β羟化酶
已知的結構
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	4ZEL
識別號
别名	DBH；, DBM, Dopamine beta-monooxygenase, dopamine beta-hydroxylase, Dopamine β-hydroxylase, ORTHYP1
外部ID	OMIM：609312 MGI：94864 HomoloGene：615 GeneCards：DBH
EC number	1.14.17.1
相關疾病
	dopamine beta-hydroxylase deficiency[1]
為以下藥物的標靶
	nepicastat[2]
基因位置（人类）
染色体	9號染色體[3]
终止	133,659,329 bp[3]
基因位置（小鼠）
染色体	小鼠2号染色体[4]
终止	27,073,212 bp[4]
RNA表达模式
	查阅更多表达数据
基因本體
分子功能	• 金屬離子結合; • monooxygenase activity; • oxidoreductase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen; • L-ascorbic acid binding; • 催化活性; • dopamine beta-monooxygenase activity; • copper ion binding;
細胞組分	• 細胞質; • transport vesicle membrane; • integral component of membrane; • chromaffin granule lumen; • chromaffin granule membrane; • cytoplasmic vesicle; • 膜; • 細胞外區域; • 細胞外空間; • secretory granule membrane; • secretory granule lumen; • 細胞內膜結合細胞器; • 内质网; • 微管组织中心;
生物學過程	• response to amphetamine; • 化学性突触传递; • homoiothermy; • leukocyte mediated immunity; • visual learning; • fear response; • behavioral response to ethanol; • locomotory behavior; • regulation of extrinsic apoptotic signaling pathway; • regulation of cell population proliferation; • positive regulation of vasoconstriction; • glucose homeostasis; • 母性行为; • 記憶; • leukocyte migration; • response to pain; • blood vessel remodeling; • cytokine production; • 联想型学习; • catecholamine biosynthetic process; • dopamine catabolic process; • norepinephrine biosynthetic process; • octopamine biosynthetic process; • positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
直系同源
	1621
	13166
	ENSG00000123454
	ENSMUSG00000000889
	P09172
	Q64237
	NM_000787
	NM_138942
	NP_000778
	NP_620392
	維基數據

多巴胺β羟化酶 （英語：，简称DBH）是一种多巴胺转化为去甲肾上腺素的酶。

Dopamine is converted to norepinephrine by the enzyme dopamine β-hydroxylase. Ascorbic acid serves as a cofactor.

多巴胺β羟化酶是一个由四个相同亚基组成的290千道尔顿加氧酶，催化需维生素C作为辅因子[7]。

另见

羟基化
多巴胺β羟化酶缺乏症

参考文献

.
.
GRCh38: Ensembl release 89: ENSG00000123454 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000889 - Ensembl, May 2017
. National Center for Biotechnology Information, U.S. National Library of Medicine.
. National Center for Biotechnology Information, U.S. National Library of Medicine.
Rush RA, Geffen LB. . Crit Rev Clin Lab Sci. 1980, 12 (3): 241–77. PMID 6998654. doi:10.3109/10408368009108731.

外部链接

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[1] .

[2] .

[refGRCh38Ensembl-3] GRCh38: Ensembl release 89: ENSG00000123454 - Ensembl, May 2017

[refGRCm38Ensembl-4] GRCm38: Ensembl release 89: ENSMUSG00000000889 - Ensembl, May 2017

[5] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[6] . National Center for Biotechnology Information, U.S. National Library of Medicine.

[7] Rush RA, Geffen LB. . Crit Rev Clin Lab Sci. 1980, 12 (3): 241–77. PMID 6998654. doi:10.3109/10408368009108731.