Trimethoprim

Trimethoprim (INN)
Reglubundið (IUPAC) navn
	5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine
Clinical data
Úttala	/traɪˈmɛθəprɪm/
Vørunavn	Proloprim, Monotrim, Triprim, onnur
AHFS/Drugs.com	monograph
MedlinePlus	a684025
Loyvi dáta	US FDA:link
Viðgongutíð; bólkur	AU: B3 ; US: C (Vandi ikki útilokaður) ;
Legal status	AU: S4 (Bara við resept) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Máti at; taka heilivágin	Gjøgnum munnin
Pharmacokinetic data
Bioavailability	90–100%
Protein binding	44%
Evnaskifti	livur
Helvtartíð	8-12 tímar
Úrskiljing	Land (50–60%), skarn (4%)
Identifiers
CAS Nummar	738-70-5
ATC code	J01EA01 QJ51EA01
PubChem	CID 5578
DrugBank	DB00440
ChemSpider	5376
UNII	AN164J8Y0X
KEGG	D00145
ChEBI	CHEBI:45924
ChEMBL	CHEMBL22
PDB ligand ID	TOP (PDBe, RCSB PDB)
Chemical data
Formula	C14H18N4O3
Molar mass	290.32 g/mol
	SMILES COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N;
	InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) ; Key:IEDVJHCEMCRBQM-UHFFFAOYSA-N ;
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Trimethoprim er eitt antibiotikum. Tað virkar við at tálma ensymið dihydrofolat reduktase (DHFR), sum er eitt týdningarmikið ensym í DNA framleiðsluni. Hetta elvir til at bakterian kemur at mangla byggisteinar til DNA, og far sostatt ikki deilt seg.

Keldur

S. P. Denyer, N. A. Hodges, S. P. Gorman, Hugo & Russel's Pharmaceutical Microbiology, 7th Edition, 2004, Blackwell Publishing.

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