Ksorfanoli

Ksorfanoli
Tunnisteet
CAS-numero	77287-89-9
IUPAC-nimi	N-(syklobutyylimetyyli)-8β-metyyli-6-metyleenimorfinan-3-oli
Ominaisuudet
Kemiallinen kaava	C23H31NO
Moolimassa	337,498 g/mol
	Infobox OKVirheellinen NIMI-arvo

Ksorfanoli (koodinimet TR-5379 tai TR-5379M, tunnetaan myös nimellä ksorfanolimesylaatti) on analgeettinen opioidi joka kuuluu morfinaaneihin, mutta sitä ei ole koskaan myyty lääkekäyttöön tai kaupallistettu.[1][2][3]

Se on opioidreseptoreiden sekä antagonisti että agonisti.[4][5]

Ksorfanoli aiheuttaa voimakkaan analgesian ja alun perin sen pääteltiin olevan niin sanotusti ei-väärinkäytettävä kemikaali.[6][7][8] Eläinkokeissa sen huomattiin aiheuttavan vain suhteellisen vähäisiä sivuvaikutuksia, ainoastaan sedaatiota ja pahoinvointia, joskin se voi aiheuttaa lihaskramppeja suuremmilla annoksilla.[9]

Lähteet

(31 October 1999) Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media, 294–. ISBN 978-0-7514-0499-9.
(10 October 1990) ANNUAL REPORTS IN MED CHEMISTRY V25 PPR. Academic Press, 12–. ISBN 978-0-08-058369-3.
Daniel Lednicer (25 June 1990). The Organic Chemistry of Drug Synthesis. Wiley, 61. ISBN 978-0-471-85548-4.
(1 January 1988) Neural Mechanisms and Biological Significance of Grooming Behavior. New York Academy of Sciences. ISBN 978-0-89766-441-7.
"Role of Opioid Receptors in Bombesin-induced Grooming" (1988). Annals of the New York Academy of Sciences 525 (1 Neural Mechan): 291–300. doi:10.1111/j.1749-6632.1988.tb38614.x. ISSN 0077-8923.
"Analgesic narcotic antagonists. 9. 6-Methylene-8 beta-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans" (1981). Journal of Medicinal Chemistry 24 (12): 1516–8. doi:10.1021/jm00144a029. PMID 6796691.
"Physical dependence induced by opiate partial agonists in the rat" (1984). Neuropeptides 5 (1–3): 11–4. doi:10.1016/0143-4179(84)90014-3. PMID 6152317.
"Xorphanol" (1985). Drug and Alcohol Dependence 14 (3–4): 373–80. doi:10.1016/0376-8716(85)90068-7. PMID 4039650.
"Preclinical toxicity and teratogenicity studies with the narcotic antagonist analgesic drug TR5379M" (1983). Fundamental and Applied Toxicology 3 (5): 478–82. doi:10.1016/S0272-0590(83)80023-2. PMID 6642105.

Aiheesta muualla

PubChem: Xorphanol (englanniksi)
ChemBlink: Xorphanol (englanniksi)

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[MortonMorton1999-1] (31 October 1999) Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media, 294–. ISBN 978-0-7514-0499-9.

[2] (10 October 1990) ANNUAL REPORTS IN MED CHEMISTRY V25 PPR. Academic Press, 12–. ISBN 978-0-08-058369-3.

[Lednicer1990-3] Daniel Lednicer (25 June 1990). The Organic Chemistry of Drug Synthesis. Wiley, 61. ISBN 978-0-471-85548-4.

[ColbernGispen1988-4] (1 January 1988) Neural Mechanisms and Biological Significance of Grooming Behavior. New York Academy of Sciences. ISBN 978-0-89766-441-7.

[GmerekCowan1988-5] "Role of Opioid Receptors in Bombesin-induced Grooming" (1988). Annals of the New York Academy of Sciences 525 (1 Neural Mechan): 291–300. doi:10.1111/j.1749-6632.1988.tb38614.x. ISSN 0077-8923.

[6] "Analgesic narcotic antagonists. 9. 6-Methylene-8 beta-alkyl-N-(cycloalkylmethyl)-3-hydroxy- or -methoxymorphinans" (1981). Journal of Medicinal Chemistry 24 (12): 1516–8. doi:10.1021/jm00144a029. PMID 6796691.

[7] "Physical dependence induced by opiate partial agonists in the rat" (1984). Neuropeptides 5 (1–3): 11–4. doi:10.1016/0143-4179(84)90014-3. PMID 6152317.

[8] "Xorphanol" (1985). Drug and Alcohol Dependence 14 (3–4): 373–80. doi:10.1016/0376-8716(85)90068-7. PMID 4039650.

[9] "Preclinical toxicity and teratogenicity studies with the narcotic antagonist analgesic drug TR5379M" (1983). Fundamental and Applied Toxicology 3 (5): 478–82. doi:10.1016/S0272-0590(83)80023-2. PMID 6642105.