FOXP2

Identifikadoreak
Taxoia	Homo sapiens
Kokapena
Hasiera	[1]
Amaiera	[2]
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Transkripzioak
Gene-adierazpen eredua
Ontologia
Funtzio-molekularrak	Ikusi DNA binding (en) ; sequence-specific DNA binding (en) ; protein homodimerization activity (en) ; DNA-binding transcription factor activity (en) ; metal ion binding (en) ; RNA polymerase II cis-regulatory region sequence-specific DNA binding (en) ; proteina lotura; protein heterodimerization activity (en) ; identical protein binding (en) ; DNA-binding transcription factor activity, RNA polymerase II-specific (en) ; androgen receptor binding (en) ; DNA-binding transcription factor activity, RNA polymerase II-specific (en) ; DNA-binding transcription repressor activity, RNA polymerase II-specific (en) ;
Osagai-zelularra	Ikusi zelula nukleo; zelula nukleo;
Prozesu-biologikoak	Ikusi positive regulation of epithelial cell proliferation involved in lung morphogenesis (en) ; regulation of transcription, DNA-templated (en) ; lung development (en) ; positive regulation of epithelial cell proliferation (en) ; negative regulation of transcription by RNA polymerase II (en) ; post-embryonic development (en) ; transcription, DNA-templated (en) ; cerebellum development (en) ; putamen development (en) ; vocal learning (en) ; positive regulation of mesenchymal cell proliferation (en) ; smooth muscle tissue development (en) ; cerebral cortex development (en) ; caudate nucleus development (en) ; camera-type eye development (en) ; lung alveolus development (en) ; righting reflex (en) ; negative regulation of transcription, DNA-templated (en) ; skeletal muscle tissue development (en) ; forebrain development (en) ; response to testosterone (en) ; innate vocalization behavior (en) ; anatomical structure morphogenesis (en) ; Zelula bereizte; growth (en) ;

Forkhead box protein P2 (FOXP2) proteina bat da, gizakietan FOXP2 geneak kodetzen duena. CAGH44, SPCH1 edo TNRC10 izenak ere baditu. Hizkuntza eta mintzoarekin lotuta dagoen genea da[3]. Ornodun ugarik duten genea da, eta askotan jokatzen du komunikazioarekin lotutako paper bat, adibidez txorien kantak garatzeko gaitasuna.

Hasiera batean, KE familiak zuen hizkuntza-nahasmendu batekin identifikatu zenean[4], FOXP2 izan zen lehen genea hitz egiteko gaitasunari lotua. Giza 7. kromosoman kokatua (7q31, SPCH1 kokapena) umeki zein helduen burmuin, bihotz, birika eta hesteetan espresioak ditu. FOXP2ren ortologoak beste ugaztun batzuetan ere identifikatu dira. Genea aktiboagoa da emeetan arretan baino.

Erreferentziak

GRCh38: Ensembl release 89:. Ensembl.
GRCh38: Ensembl release 89:. Ensembl.
(Ingelesez) Lai, Cecilia S. L.; Fisher, Simon E.; Hurst, Jane A.; Vargha-Khadem, Faraneh; Monaco, Anthony P.. (2001-10). «A forkhead-domain gene is mutated in a severe speech and language disorder» Nature 413 (6855): 519–523. doi:10.1038/35097076. ISSN 0028-0836. (Noiz kontsultatua: 2018-11-21).
(Ingelesez) Nudel, Ron; Newbury, Dianne F. (2013-08-13). «FOXP2» Wiley Interdisciplinary Reviews: Cognitive Science 4 (5): 547–560. doi:10.1002/wcs.1247. ISSN 1939-5078. PMID 24765219. PMC PMC3992897. (Noiz kontsultatua: 2018-11-21).

Kanpo estekak

Datuak: Q227241
Multimedia: FOXP2 / Q227241

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[1] GRCh38: Ensembl release 89:. Ensembl.

[2] GRCh38: Ensembl release 89:. Ensembl.

[3] (Ingelesez) Lai, Cecilia S. L.; Fisher, Simon E.; Hurst, Jane A.; Vargha-Khadem, Faraneh; Monaco, Anthony P.. (2001-10). «A forkhead-domain gene is mutated in a severe speech and language disorder» Nature 413 (6855): 519–523. doi:10.1038/35097076. ISSN 0028-0836. (Noiz kontsultatua: 2018-11-21).

[4] (Ingelesez) Nudel, Ron; Newbury, Dianne F. (2013-08-13). «FOXP2» Wiley Interdisciplinary Reviews: Cognitive Science 4 (5): 547–560. doi:10.1002/wcs.1247. ISSN 1939-5078. PMID 24765219. PMC PMC3992897. (Noiz kontsultatua: 2018-11-21).