CYP2C8

CYP2C8
	Proteinak kodetzen dituen genea
Identifikadoreak
	Homologene: 117948 Genenames: CYP2C8 Ensemble: ENSG00000138115
Taxoia	Homo sapiens
Asoziazio-genetikoa	Baztanga; osteonecrosis (en)
Kokapena
Kromosoma	human chromosome 10 (en)
Kokapen zitogenetikoa	10q23.33
Hasiera	95036772 bp[1]
Amaiera	95069497 bp[2]
Transkripzioak
RNA ID	NM_000770, NM_001198853, NM_001198854, NM_001198855 eta NM_030878
Ensembl	Zerrenda ENST00000628935; ENST00000371270; ENST00000479946; ENST00000490994; ENST00000525991; ENST00000526814; ENST00000527420; ENST00000527953; ENST00000531714; ENST00000533320; ENST00000535898; ENST00000623108;
Beste espezieetan
Sagu arrunt	Cyp2c39 (en)
Sagu arrunt	Cyp2c29 (en)
Arratoi arrunt	Cyp2c7 (en)
Sagu arrunt	Cyp2c38 (en)
Gene-adierazpen eredua
Ontologia
Kodetzen du	cytochrome P450 family 2 subfamily C member 8 (en)
Funtzio-molekularrak	Ikusi oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (en) ; caffeine oxidase activity (en) ; aromatase activity (en) ; oxidoreductase activity (en) ; heme binding (en) ; metal ion binding (en) ; iron ion binding (en) ; arachidonic acid epoxygenase activity (en) ; monooxygenase activity (en) ; estrogen 16-alpha-hydroxylase activity (en) ; steroid hydroxylase activity (en) ; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen (en) ; heme binding (en) ; monooxygenase activity (en) ;
Osagai-zelularra	Ikusi Erretikulu endoplasmatiko; organelle membrane (en) ; mintza; intracellular membrane-bounded organelle (en) ; endoplasmic reticulum membrane (en) ; zitoplasma; intracellular membrane-bounded organelle (en) ;
Prozesu-biologikoak	Ikusi omega-hydroxylase P450 pathway (en) ; organic acid metabolic process (en) ; epoxygenase P450 pathway (en) ; oxidative demethylation (en) ; xenobiotic metabolic process (en) ; lipid hydroxylation (en) ; steroid metabolic process (en) ; long-chain fatty acid biosynthetic process (en) ; organic acid metabolic process (en) ; xenobiotic metabolic process (en) ; estrogen metabolic process (en) ;

P450 2C8 zitokromoa (CYP2C8) P450 zitokromoaren proteina-multzoko entzima da. Entzima horrek zerikusia du, besteak beste, paclitaxel, repaglinida, rosiglitazona eta zeribastatina botiken metabolismoan. Lehen, "P450 zitokromoa, IIC subfamilia (mefenitoina 4-hidroxilasa), 8 polipeptidoa" deitzen zitzaion.[3]

CYP2C8aren inhibitzaileak

Identifikaturiko inhibitzaile indartsuena leukotrieno-hartzailearen antagonista izan zen, montelukast. CYP2C8aren beste inhibitzaile batzuk klase terapeutiko ugariren bidez identifikatu ziren, klase bakar bat nagusitu gabe. Inhibitzaile indartsu horien artean daude candesartan zilexetiloa (txirristako profarmakoa), zafirlukast, clotrimazola, felodipinoa eta mometasonaren furoatoa.[4]

Erreferentziak

GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.
GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.
genenames.org. CYP2C8. .
Walsky, RL; Gaman EA; Obach RS.. (Jan de 2005). «Examination of 209 drugs for inhibition of cytochrome P450 2C8.» J. Clin. Pharmacol 45 (1): 68..

Kanpo estekak

Datuak: Q14916190

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[1] GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.

[2] GRCh38: Ensembl release 89: ENSG00000138115. Ensembl.

[3] s.org. CYP2C8. .

[4] Walsky, RL; Gaman EA; Obach RS.. (Jan de 2005). «Examination of 209 drugs for inhibition of cytochrome P450 2C8.» J. Clin. Pharmacol 45 (1): 68..