CCL5

CCL5
	nach PDB 1EQT
Andere Namen	RANTES; Chemokine (C-C Motif) Ligand 5; SIS-Delta; D17S136E; TCP228; Eosinophil Chemotactic Cytokine; T-Cell Specific Protein P288; Beta-Chemokine; EoCP; Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5;; C-C Motif Chemokine 5;
	Vorhandene Strukturdaten: 1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L
Eigenschaften des menschlichen Proteins
Masse/Länge Primärstruktur	91 Aminosäuren, 9990 Da
Bezeichner
Externe IDs	GeneCards: CCL5; OMIM: 187011; UniProt: P13501;
Vorkommen
Homologie-Familie	Hovergen
	Orthologe

CCL5 (englisch CC-chemokine ligand 5) ist ein Zytokin aus der Familie der CC-Chemokine.

Eigenschaften

CCL5 ist an Entzündungsprozessen beteiligt. CCL5 wird unter anderem von zytotoxischen T-Zellen gebildet und bindet T-Zellen, Monozyten und Eosinophile durch Bindung der Rezeptoren CCR3,[1][2] CCR5[2][3][4] und CCR1.[2][4] CCL5 aktiviert den GPCR GPR75.[5]

CCL5 ist an der Abwehr von Infektionen mit HIV-1 beteiligt,[6] da es die Bindung von HIV an seinen Korezeptor CCR5 kompetitiv hemmt.

Einzelnachweise

Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor. In: J. Exp. Med. 183. Jahrgang, Nr. 5, Mai 1996, S. 2349–54, doi:10.1084/jem.183.5.2349, PMID 8642344, PMC 2192548 (freier Volltext).
Struyf S, Menten P, Lenaerts JP, Put W, D’Haese A, De Clercq E, Schols D, Proost P, Van Damme J: Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. In: Eur. J. Immunol. 31. Jahrgang, Nr. 7, Juli 2001, S. 2170–8, doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D, PMID 11449371.
Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L: Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages. In: Biochim. Biophys. Acta. 1617. Jahrgang, Nr. 1–2, Oktober 2003, S. 80–8, doi:10.1016/j.bbamem.2003.09.006, PMID 14637022.
Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN: The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. In: J. Biol. Chem. 276. Jahrgang, Nr. 14, April 2001, S. 10620–6, doi:10.1074/jbc.M010867200, PMID 11116158.
Ignatov A, Robert J, Gregory-Evans C, Schaller HC: RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. In: Br. J. Pharmacol. 149. Jahrgang, Nr. 5, November 2006, S. 490–7, doi:10.1038/sj.bjp.0706909, PMID 17001303, PMC 2014681 (freier Volltext).
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. In: Science. 270. Jahrgang, Nr. 5243, Dezember 1995, S. 1811–5, doi:10.1126/science.270.5243.1811, PMID 8525373 (sciencemag.org).

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[pmid8642344-1] Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: Cloning, expression, and characterization of the human eosinophil eotaxin receptor. In: J. Exp. Med. 183. Jahrgang, Nr. 5, Mai 1996, S. 2349–54, doi:10.1084/jem.183.5.2349, PMID 8642344, PMC 2192548 (freier Volltext).

[pmid11449371-2] Struyf S, Menten P, Lenaerts JP, Put W, D’Haese A, De Clercq E, Schols D, Proost P, Van Damme J: Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. In: Eur. J. Immunol. 31. Jahrgang, Nr. 7, Juli 2001, S. 2170–8, doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D, PMID 11449371.

[pmid14637022-3] Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L: Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages. In: Biochim. Biophys. Acta. 1617. Jahrgang, Nr. 1–2, Oktober 2003, S. 80–8, doi:10.1016/j.bbamem.2003.09.006, PMID 14637022.

[pmid11116158-4] Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN: The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. In: J. Biol. Chem. 276. Jahrgang, Nr. 14, April 2001, S. 10620–6, doi:10.1074/jbc.M010867200, PMID 11116158.

[pmid17001303-5] Ignatov A, Robert J, Gregory-Evans C, Schaller HC: RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. In: Br. J. Pharmacol. 149. Jahrgang, Nr. 5, November 2006, S. 490–7, doi:10.1038/sj.bjp.0706909, PMID 17001303, PMC 2014681 (freier Volltext).

[pmid8525373-6] Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. In: Science. 270. Jahrgang, Nr. 5243, Dezember 1995, S. 1811–5, doi:10.1126/science.270.5243.1811, PMID 8525373 (sciencemag.org).