c-Jun

c-Jun ist am Zellzyklus und der Apoptose beteiligt. Mutationen im Gen von c-Jun treten bei verschiedenen Tumoren auf. c-Jun war der erste beschriebene onkogene Transkriptionsfaktor.[2] Das Homolog des c-Jun (englisch cellular Jun) aus Retroviren wird als v-Jun (englisch viral Jun) bezeichnet.[3]

c-Jun interagiert mit verschiedenen Proteinen:

• TGIF1[4]
• Ets Related Gene[5]
• Retinoblastom-Protein[6]
• CREBBP[7]
• ATF2[8][9][10]
• BRCA1-Cofaktor[11]
• BRCA1[12]
• c-Fos[13][14][15][16][17][18][19]
• NFE2L1[19]
• DDX21[20]
• NFE2L2[19]
• TATA-bindendes Protein[21]
• RELA[16]
• MAPK8[22][23][24][25][26][27][28][29]
• NCOR2[30]
• RFWD2[31][32]
• PIN1[33]
• FOSL1[14]
• SMAD3[34][35][36]
• ASCC3[37]
• TFIIB[21]
• CSNK2A2[38]
• CSNK2A1[38]
• STAT1[39]
• BCL6[40]
• BCL3[41]
• Receptor androgénico[42]
• STAT3[39]
• ETS2[43]
• ATF3[44][45][10]
• NACA[46]
• COPS5[47]
• DDIT3[48]
• RBM39[49]
• NCOA1[50][51][52]
• MyoD[53]
• RUNX2[54][55]
• RUNX1[54][55]

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30. S. K. Lee, J. H. Kim, Y. C. Lee, J. Cheong, J. W. Lee: Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor. In: The Journal of biological chemistry. Band 275, Nummer 17, April 2000, S. 12470–12474, PMID 10777532.
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33. G. M. Wulf, A. Ryo, G. G. Wulf, S. W. Lee, T. Niu, V. Petkova, K. P. Lu: Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. In: The EMBO journal. Band 20, Nummer 13, Juli 2001, S. 3459–3472, doi:10.1093/emboj/20.13.3459, PMID 11432833, PMC 125530 (freier Volltext).
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43. J. P. Basuyaux, E. Ferreira, D. Stéhelin, G. Butticè: The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. In: The Journal of biological chemistry. Band 272, Nummer 42, Oktober 1997, S. 26188–26195, PMID 9334186.
44. A. G. Pearson, C. W. Gray, J. F. Pearson, J. M. Greenwood, M. J. During, M. Dragunow: ATF3 enhances c-Jun-mediated neurite sprouting. In: Brain research. Molecular brain research. Band 120, Nummer 1, Dezember 2003, S. 38–45, PMID 14667575.
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