ZIC2
ZIC2 (Zic family member 2) هوَ بروتين يُشَفر بواسطة جين ZIC2 في الإنسان.[1][2][3]
الوظيفة
المراجع
- Brown SA، Warburton D، Brown LY، Yu CY، Roeder ER، Stengel-Rutkowski S، Hennekam RC، Muenke M (1998). "Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired". Nat Genet. ج. 20 ع. 2: 180–3. DOI:10.1038/2484. PMID:9771712.
- "Entrez Gene: ZIC2 Zic family member 2 (odd-paired homolog, Drosophila)". مؤرشف من الأصل في 2010-12-05.
- Ali RG، Bellchambers HM، Arkell RM (نوفمبر 2012). "Zinc finger of the cerebellum (Zic): Transcription factors and co-factors". Int J Biochem Cell Biol. ج. 44 ع. 11: 2065–8. DOI:10.1016/j.biocel.2012.08.012. PMID:22964024.
قراءة متعمقة
- Houtmeyers R، Souopgui J، Tejpar S، Arkell R (2013). "The ZIC gene family encodes multi-functional proteins essential for patterning and morphogenesis". Cell Mol Life Sci. ج. 70 ع. 20: 3791–811. DOI:10.1007/s00018-013-1285-5. PMID:23443491.
- Brown S، Gersen S، Anyane-Yeboa K، Warburton D (1993). "Preliminary definition of a "critical region" of chromosome 13 in q32: report of 14 cases with 13q deletions and review of the literature". Am. J. Med. Genet. ج. 45 ع. 1: 52–9. DOI:10.1002/ajmg.1320450115. PMID:8418661.
- Brown LY، Odent S، David V، Blayau M، Dubourg C، Apacik C، Delgado MA، Hall BD، Reynolds JF، Sommer A، Wieczorek D، Brown SA، Muenke M (2001). "Holoprosencephaly due to mutations in ZIC2: alanine tract expansion mutations may be caused by parental somatic recombination". Hum. Mol. Genet. ج. 10 ع. 8: 791–6. DOI:10.1093/hmg/10.8.791. PMID:11285244.
- Dubourg C، Lazaro L، Pasquier L، Bendavid C، Blayau M، Le Duff F، Durou MR، Odent S، David V (2004). "Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations". Hum. Mutat. ج. 24 ع. 1: 43–51. DOI:10.1002/humu.20056. PMID:15221788.
- Brown L، Paraso M، Arkell R، Brown S (2005). "In vitro analysis of partial loss-of-function ZIC2 mutations in holoprosencephaly: alanine tract expansion modulates DNA binding and transactivation". Hum. Mol. Genet. ج. 14 ع. 3: 411–20. DOI:10.1093/hmg/ddi037. PMID:15590697.
- Ishiguro A، Ideta M، Mikoshiba K، Chen DJ، Aruga J (2007). "ZIC2-dependent transcriptional regulation is mediated by DNA-dependent protein kinase, poly(ADP-ribose) polymerase, and RNA helicase A". J. Biol. Chem. ج. 282 ع. 13: 9983–95. DOI:10.1074/jbc.M610821200. PMID:17251188.
بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
بوابة الكيمياء الحيوية
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