WNT7A
WNT7A (Wnt family member 7A) هوَ بروتين يُشَفر بواسطة جين WNT7A في الإنسان.[1][2][3]
الوظيفة
المراجع
- "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A". مؤرشف من الأصل في 2010-12-05.
- Bui TD، Lako M، Lejeune S، Curtis AR، Strachan T، Lindsay S، Harris AL (يونيو 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. ج. 189 ع. 1: 25–9. DOI:10.1016/S0378-1119(96)00808-6. PMID:9161407.
- Ikegawa S، Kumano Y، Okui K، Fujiwara T، Takahashi E، Nakamura Y (ديسمبر 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet. ج. 74 ع. 1–2: 149–52. DOI:10.1159/000134404. PMID:8893824.
قراءة متعمقة
- Smolich BD، McMahon JA، McMahon AP، Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. ج. 4 ع. 12: 1267–75. DOI:10.1091/mbc.4.12.1267. PMC:275763. PMID:8167409.
- Huguet EL، McMahon JA، McMahon AP، وآخرون (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. ج. 54 ع. 10: 2615–21. PMID:8168088.
- Parr BA، McMahon AP (1998). "Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a". Nature. ج. 395 ع. 6703: 707–10. DOI:10.1038/27221. PMID:9790192.
- Calvo R، West J، Franklin W، وآخرون (2001). "Altered HOX and WNT7A expression in human lung cancer". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 23: 12776–81. DOI:10.1073/pnas.97.23.12776. PMC:18840. PMID:11070089.
- Li S، Chiang TC، Davis GR، وآخرون (2001). "Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma". J. Clin. Endocrinol. Metab. ج. 86 ع. 1: 454–7. DOI:10.1210/jc.86.1.454. PMID:11232041.
- Couse JF، Dixon D، Yates M، وآخرون (2002). "Estrogen receptor-alpha knockout mice exhibit resistance to the developmental effects of neonatal diethylstilbestrol exposure on the female reproductive tract". Dev. Biol. ج. 238 ع. 2: 224–38. DOI:10.1006/dbio.2001.0413. PMID:11784006.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Caricasole A، Ferraro T، Iacovelli L، وآخرون (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins". J. Biol. Chem. ج. 278 ع. 39: 37024–31. DOI:10.1074/jbc.M300191200. PMID:12857724.
- Tuli R، Tuli S، Nandi S، وآخرون (2003). "Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk". J. Biol. Chem. ج. 278 ع. 42: 41227–36. DOI:10.1074/jbc.M305312200. PMID:12893825.
- Ohira T، Gemmill RM، Ferguson K، وآخرون (2003). "WNT7a induces E-cadherin in lung cancer cells". Proc. Natl. Acad. Sci. U.S.A. ج. 100 ع. 18: 10429–34. DOI:10.1073/pnas.1734137100. PMC:193578. PMID:12937339.
- Timmreck LS، Pan HA، Reindollar RH، Gray MR (2004). "WNT7A mutations in patients with Müllerian duct abnormalities". Journal of pediatric and adolescent gynecology. ج. 16 ع. 4: 217–21. DOI:10.1016/S1083-3188(03)00124-4. PMID:14550385.
- Hwang SG، Ryu JH، Kim IC، وآخرون (2004). "Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms". J. Biol. Chem. ج. 279 ع. 25: 26597–604. DOI:10.1074/jbc.M401401200. PMID:15082716.
- Winn RA، Marek L، Han SY، وآخرون (2005). "Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation". J. Biol. Chem. ج. 280 ع. 20: 19625–34. DOI:10.1074/jbc.M409392200. PMID:15705594.
- Lyu J، Joo CK (2005). "Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing". J. Biol. Chem. ج. 280 ع. 22: 21653–60. DOI:10.1074/jbc.M500374200. PMID:15802269.
- Woods CG، Stricker S، Seemann P، وآخرون (2006). "Mutations in WNT7A Cause a Range of Limb Malformations, Including Fuhrmann Syndrome and Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome". Am. J. Hum. Genet. ج. 79 ع. 2: 402–8. DOI:10.1086/506332. PMC:1559483. PMID:16826533.
- Winn RA، Van Scoyk M، Hammond M، وآخرون (2006). "Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma". J. Biol. Chem. ج. 281 ع. 37: 26943–50. DOI:10.1074/jbc.M604145200. PMID:16835228.
- Lindberg D، Akerström G، Westin G (2007). "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours". Clin. Endocrinol. ج. 66 ع. 1: 110–4. DOI:10.1111/j.1365-2265.2006.02694.x. PMID:17201809.
- Thrasivoulou C، Millar M، Ahmed A (2013). "Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways". J. Biol. Chem. ج. 288 ع. 50: 35651–35659. DOI:10.1074/jbc.M112.437913. PMC:3861617. PMID:24158438.
{{استشهاد بدورية محكمة}}
: الوسيط غير المعروف|last-author-amp=
تم تجاهله يقترح استخدام|name-list-style=
(مساعدة)
- بوابة علم الأحياء الخلوي والجزيئي
- بوابة طب
- بوابة الكيمياء الحيوية
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