TREM2

TREM2
المعرفات
الأسماء المستعارة	TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 605086 MGI: MGI:1913150 HomoloGene: 10352 GeneCards: 54209
علم الوجود الجيني
الوظيفة الجزيئية	• scaffold protein binding; • lipopolysaccharide binding; • lipoteichoic acid binding; • peptidoglycan binding; • phospholipid binding; • signaling receptor activity; • amyloid-beta binding; • high-density lipoprotein particle binding; • lipid binding; • low-density lipoprotein particle binding; • apolipoprotein binding; • apolipoprotein A-I binding; • very-low-density lipoprotein particle binding; • ‏GO:0032403 protein-containing complex binding; • lipoprotein particle binding; • protein tyrosine kinase binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني;
المكونات الخلوية	• مكون تكاملي للغشاء; • غشاء; • منطقة خارج الخلية; • غشاء خلوي; • integral component of plasma membrane; • intrinsic component of plasma membrane;
العمليات الحيوية	• dendritic cell differentiation; • positive regulation of CD40 signaling pathway; • positive regulation of calcium-mediated signaling; • positive regulation of C-C chemokine receptor CCR7 signaling pathway; • phagocytosis, engulfment; • detection of peptidoglycan; • humoral immune response; • cellular response to lipoteichoic acid; • positive regulation of protein localization to plasma membrane; • regulation of immune response; • positive regulation of peptidyl-tyrosine phosphorylation; • detection of lipoteichoic acid; • مناعة فطرية; • detection of lipopolysaccharide; • cellular response to peptidoglycan; • positive regulation of antigen processing and presentation of peptide antigen via MHC class II; • positive regulation of ERK1 and ERK2 cascade; • ‏GO:0072468 توصيل الإشارة; • osteoclast differentiation; • positive regulation of macrophage fusion; • positive regulation of amyloid-beta clearance; • positive regulation of protein phosphorylation; • تنظيم التعبير الجيني; • negative regulation of autophagy; • ‏GO:1901313 positive regulation of gene expression; • positive regulation of mitochondrion organization; • regulation of TOR signaling; • positive regulation of TOR signaling; • regulation of interleukin-6 production; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of chemotaxis; • regulation of resting membrane potential; • positive regulation of astrocyte activation; • regulation of macrophage inflammatory protein 1 alpha production; • import into cell; • regulation of plasma membrane bounded cell projection organization; • positive regulation of proteasomal protein catabolic process; • positive regulation of inward rectifier potassium channel activity; • regulation of intracellular signal transduction; • positive regulation of microglial cell activation; • negative regulation of autophagic cell death; • positive regulation of microglial cell migration; • cellular response to amyloid-beta; • positive regulation of CAMKK-AMPK signaling cascade; • positive regulation of ATP biosynthetic process; • apoptotic cell clearance; • positive regulation of protein secretion; • microglial cell activation; • response to ischemia; • negative regulation of interleukin-1 beta production; • negative regulation of tumor necrosis factor production; • positive regulation of interleukin-10 production; • negative regulation of apoptotic process; • positive regulation of osteoclast differentiation; • positive regulation of NIK/NF-kappaB signaling; • microglial cell activation involved in immune response; • defense response to bacterium; • regulation of innate immune response; • positive regulation of phagocytosis, engulfment; • microglial cell proliferation; • amyloid-beta clearance; • complement-mediated synapse pruning; • neuroinflammatory response; • positive regulation of neuroinflammatory response; • positive regulation of engulfment of apoptotic cell;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q9NZC2
	Q99NH8
	‏NM_018965 NM_001271821، ‏NM_018965
	‏NM_031254 NM_001272078، ‏NM_031254
	‏NP_061838 NP_001258750، ‏NP_061838
	‏NP_112544 NP_001259007، ‏NP_112544
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

TREM2 (اختصارًا لاسم Triggering receptor expressed on myeloid cells 2) هو بروتين في البشر يُشفر عبر جين TREM2.[1][2][3]

المراجع

Bouchon A، Dietrich J، Colonna M (مايو 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology. ج. 164 ع. 10: 4991–5. DOI:10.4049/jimmunol.164.10.4991. PMID:10799849.
Paloneva J، Manninen T، Christman G، Hovanes K، Mandelin J، Adolfsson R، Bianchin M، Bird T، Miranda R، Salmaggi A، Tranebjaerg L، Konttinen Y، Peltonen L (سبتمبر 2002). "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype". American Journal of Human Genetics. ج. 71 ع. 3: 656–62. DOI:10.1086/342259. PMC:379202. PMID:12080485.
"Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2". مؤرشف من الأصل في 2010-03-07.

بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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[pmid10799849-1] Bouchon A، Dietrich J، Colonna M (مايو 2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". Journal of Immunology. ج. 164 ع. 10: 4991–5. DOI:10.4049/jimmunol.164.10.4991. PMID:10799849.

[pmid12080485-2] Paloneva J، Manninen T، Christman G، Hovanes K، Mandelin J، Adolfsson R، Bianchin M، Bird T، Miranda R، Salmaggi A، Tranebjaerg L، Konttinen Y، Peltonen L (سبتمبر 2002). "Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype". American Journal of Human Genetics. ج. 71 ع. 3: 656–62. DOI:10.1086/342259. PMC:379202. PMID:12080485.

[entrez-3] "Entrez Gene: TREM2 triggering receptor expressed on myeloid cells 2". مؤرشف من الأصل في 2010-03-07.

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 605086
المعرفات الخارجية	Ensembl Transcript ID: ENST00000373113 نظام اللغة الطبية الموحدة (UMLS CUI): C1425067