TPPP
TPPP (Tubulin polymerization promoting protein) هوَ بروتين يُشَفر بواسطة جين TPPP في الإنسان.[1][2][3][4][5][6][7][8]
الوظيفة
المراجع
- Hlavanda E، Kovacs J، Olah J، Orosz F، Medzihradszky KF، Ovadi J (يوليو 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. ج. 41 ع. 27: 8657–64. DOI:10.1021/bi020140g. PMID:12093283.
- "Entrez Gene: TPPP brain-specific protein p25 alpha". مؤرشف من الأصل في 2010-12-05.
- Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (23 Nov 2006). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica (بالإنجليزية). 113 (2): 153–161. DOI:10.1007/s00401-006-0167-4. ISSN:0001-6322. PMID:17123092. Archived from the original on 2018-06-14.
- Vincze O، Tokesi N، Olah J، Hlavanda E، Zotter A، Horvath I، Lehotzky A، Tirian L، Medzihradszky KF، Kovacs J، Orosz F، Ovadi J (نوفمبر 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. ج. 45 ع. 46: 13818–26. DOI:10.1021/bi061305e. PMID:17105200.
- Lindersson E، Lundvig D، Petersen C، Madsen P، Nyengaard JR، Hojrup P، Moos T، Otzen D، Gai WP، Blumbergs PC، Jensen PH (فبراير 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. ج. 280 ع. 7: 5703–15. DOI:10.1074/jbc.M410409200. PMID:15590652.
- Kovács، Gábor G.؛ László، Lajos؛ Kovács، János؛ Jensen، Poul Henning؛ Lindersson، Evo؛ Botond، Gergő؛ Molnár، Tamás؛ Perczel، András؛ Hudecz، Ferenc (1 نوفمبر 2004). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. ج. 17 ع. 2: 155–162. DOI:10.1016/j.nbd.2004.06.006. مؤرشف من الأصل في 2019-12-07.
- Seki N، Hattori A، Sugano S، Suzuki Y، Nakagawara A، Muramatsu M، Hori T، Saito T (أبريل 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. ج. 44 ع. 2: 121–2. DOI:10.1007/s100380050122. PMID:10083737.
- Vincze O، Oláh J، Zádori D، Klivényi P، Vécsei L، Ovádi J (مايو 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. ج. 409 ع. 1: 137–41. DOI:10.1016/j.bbrc.2011.04.130. PMID:21565174.
قراءة متعمقة
- Bonaldo MF، Lennon G، Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. ج. 6 ع. 9: 791–806. DOI:10.1101/gr.6.9.791. PMID:8889548.
- Martín CP، Vázquez J، Avila J، Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta. ج. 1586 ع. 1: 113–22. DOI:10.1016/s0925-4439(01)00092-8. PMID:11781156.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Tirián L، Hlavanda E، Oláh J، وآخرون (2004). "TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation". Proc. Natl. Acad. Sci. U.S.A. ج. 100 ع. 24: 13976–81. DOI:10.1073/pnas.2436331100. PMC:283531. PMID:14623963.
- Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
- Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
- Lehotzky A، Tirián L، Tökési N، وآخرون (2005). "Dynamic targeting of microtubules by TPPP/p25 affects cell survival". J. Cell Sci. ج. 117 ع. Pt 25: 6249–59. DOI:10.1242/jcs.01550. PMID:15564385.
- DeGiorgis JA، Jaffe H، Moreira JE، وآخرون (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". J. Proteome Res. ج. 4 ع. 2: 306–15. DOI:10.1021/pr0498436. PMID:15822905.
- Jämsä A، Bäckström A، Gustafsson E، وآخرون (2006). "Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells". Biochem. Biophys. Res. Commun. ج. 345 ع. 1: 324–31. DOI:10.1016/j.bbrc.2006.04.032. PMID:16678793.
- Skjoerringe T، Lundvig DM، Jensen PH، Moos T (2006). "P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain". J. Neurochem. ج. 99 ع. 1: 333–42. DOI:10.1111/j.1471-4159.2006.04073.x. PMID:16879710.
- Oláh J، Tokési N، Vincze O، وآخرون (2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies". FEBS Lett. ج. 580 ع. 25: 5807–14. DOI:10.1016/j.febslet.2006.09.037. PMID:17027006.
- Hlavanda E، Klement E، Kókai E، وآخرون (2007). "Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases". J. Biol. Chem. ج. 282 ع. 40: 29531–9. DOI:10.1074/jbc.M703466200. PMID:17693641.
- Song YJ، Lundvig DM، Huang Y، وآخرون (2007). "p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy". Am. J. Pathol. ج. 171 ع. 4: 1291–303. DOI:10.2353/ajpath.2007.070201. PMC:1988878. PMID:17823288.
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