TLX3
TLX3 (T cell leukemia homeobox 3) هوَ بروتين يُشَفر بواسطة جين TLX3 في الإنسان.[1][2][3]
الوظيفة
المراجع
- "Entrez Gene: TLX3 T-cell leukemia homeobox 3". مؤرشف من الأصل في 2010-12-05.
- Lee-Kirsch MA، Engel K، Paditz E، Rosen-Wolff A، Lee YA، Gahr M (يوليو 2001). "Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34→q35 by radiation hybrid mapping". Cytogenet Cell Genet. ج. 92 ع. 3–4: 358. DOI:10.1159/000056933. PMID:11435718.
- Cinti R، Fava M، Sancandi M، Matera I، Ravazzolo R، Ceccherini I (يوليو 2001). "Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization". Cytogenet Cell Genet. ج. 92 ع. 3–4: 354–5. DOI:10.1159/000056931. PMID:11435716.
قراءة متعمقة
- Dear TN، Sanchez-Garcia I، Rabbitts TH (1993). "The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes". Proc. Natl. Acad. Sci. U.S.A. ج. 90 ع. 10: 4431–5. DOI:10.1073/pnas.90.10.4431. PMC:46525. PMID:8099440.
- Bernard OA، Busson-LeConiat M، Ballerini P، وآخرون (2002). "A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia". Leukemia. ج. 15 ع. 10: 1495–504. DOI:10.1038/sj.leu.2402249. PMID:11587205.
- Ballerini P، Blaise A، Busson-Le Coniat M، وآخرون (2002). "HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis". Blood. ج. 100 ع. 3: 991–7. DOI:10.1182/blood-2001-11-0093. PMID:12130513.
- Matera I، Bachetti T، Cinti R، وآخرون (2003). "Mutational analysis of the RNX gene in congenital central hypoventilation syndrome". Am. J. Med. Genet. ج. 113 ع. 2: 178–82. DOI:10.1002/ajmg.10746. PMID:12407709.
- Mauvieux L، Leymarie V، Helias C، وآخرون (2003). "High incidence of Hox11L2 expression in children with T-ALL". Leukemia. ج. 16 ع. 12: 2417–22. DOI:10.1038/sj.leu.2402709. PMID:12454747.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Berger R، Dastugue N، Busson M، وآخرون (2003). "t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)". Leukemia. ج. 17 ع. 9: 1851–7. DOI:10.1038/sj.leu.2403061. PMID:12970786.
- Cavé H، Suciu S، Preudhomme C، وآخرون (2004). "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951". Blood. ج. 103 ع. 2: 442–50. DOI:10.1182/blood-2003-05-1495. PMID:14504110.
- Su XY، Busson M، Della Valle V، وآخرون (2004). "Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia". Genes Chromosomes Cancer. ج. 41 ع. 3: 243–9. DOI:10.1002/gcc.20088. PMID:15334547.
- Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
- Ballerini P، Busson M، Fasola S، وآخرون (2005). "NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance". Leukemia. ج. 19 ع. 3: 468–70. DOI:10.1038/sj.leu.2403654. PMID:15674415.
- Gottardo NG، Jacoby PA، Sather HN، وآخرون (2005). "Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols". Leukemia. ج. 19 ع. 9: 1705–8. DOI:10.1038/sj.leu.2403834. PMID:15990867.
- Borghini S، Vargiolu M، Di Duca M، وآخرون (2006). "Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia". Mol. Cancer Res. ج. 4 ع. 9: 635–43. DOI:10.1158/1541-7786.MCR-05-0250. PMID:16966433.
- Nagel S، Scherr M، Kel A، وآخرون (2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Res. ج. 67 ع. 4: 1461–71. DOI:10.1158/0008-5472.CAN-06-2615. PMID:17308084.
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي
بوابة الكيمياء الحيوية
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