TIMP3
TIMP3 (TIMP metallopeptidase inhibitor 3) هوَ بروتين يُشَفر بواسطة جين TIMP3 في الإنسان.[1][2][3]
الوظيفة
المراجع
- "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)". مؤرشف من الأصل في 2010-12-05.
- Qi JH، Ebrahem Q، Moore N، Murphy G، Claesson-Welsh L، Bond M، Baker A، Anand-Apte B (أبريل 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. ج. 9 ع. 4: 407–15. DOI:10.1038/nm846. PMID:12652295.
- Apte SS، Mattei MG، Olsen BR (يونيو 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. ج. 19 ع. 1: 86–90. DOI:10.1006/geno.1994.1016. PMID:8188246.
قراءة متعمقة
- Li Z، Clarke MP، Barker MD، McKie N (2007). "TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights". Expert Reviews in Molecular Medicine. ج. 7 ع. 24: 1–15. DOI:10.1017/S1462399405010045. PMID:16259644.
- Docherty AJ، Lyons A، Smith BJ، وآخرون (1985). "Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity". Nature. ج. 318 ع. 6041: 66–9. Bibcode:1985Natur.318...66D. DOI:10.1038/318066a0. PMID:3903517.
- Forsius HR، Eriksson AW، Suvanto EA، Alanko HI (1983). "Pseudoinflammatory fundus dystrophy with autosomal recessive inheritance". Am. J. Ophthalmol. ج. 94 ع. 5: 634–49. DOI:10.1016/0002-9394(82)90009-5. PMID:7148944.
- Wick M، Härönen R، Mumberg D، وآخرون (1995). "Structure of the human TIMP-3 gene and its cell cycle-regulated promoter". Biochem. J. 311. ( Pt 2): 549–54. PMC:1136034. PMID:7487894.
- Jacobson SG، Cideciyan AV، Regunath G، وآخرون (1995). "Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.". Nat. Genet. ج. 11 ع. 1: 27–32. DOI:10.1038/ng0995-27. PMID:7550309.
- Higuchi T، Kanzaki H، Nakayama H، وآخرون (1995). "Induction of tissue inhibitor of metalloproteinase 3 gene expression during in vitro decidualization of human endometrial stromal cells". Endocrinology. ج. 136 ع. 11: 4973–81. DOI:10.1210/en.136.11.4973. PMID:7588231.
- Wilde CG، Hawkins PR، Coleman RT، وآخرون (1995). "Cloning and characterization of human tissue inhibitor of metalloproteinases-3". DNA Cell Biol. ج. 13 ع. 7: 711–8. DOI:10.1089/dna.1994.13.711. PMID:7772252.
- Apte SS، Olsen BR، Murphy G (1995). "The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family". J. Biol. Chem. ج. 270 ع. 24: 14313–8. DOI:10.1074/jbc.270.24.14313. PMID:7782289.
- Kishnani NS، Staskus PW، Yang TT، وآخرون (1995). "Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix". Matrix Biol. ج. 14 ع. 6: 479–88. DOI:10.1016/0945-053X(95)90005-5. PMID:7795886.
- Weber BH، Vogt G، Pruett RC، وآخرون (1995). "Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy". Nat. Genet. ج. 8 ع. 4: 352–6. DOI:10.1038/ng1294-352. PMID:7894485.
- Weber BH، Vogt G، Wolz W، وآخرون (1994). "Sorsby's fundus dystrophy is genetically linked to chromosome 22q13-qter". Nat. Genet. ج. 7 ع. 2: 158–61. DOI:10.1038/ng0694-158. PMID:7920634.
- Jones SE، Jomary C، Neal MJ (1994). "Expression of TIMP3 mRNA is elevated in retinas affected by simplex retinitis pigmentosa". FEBS Lett. ج. 352 ع. 2: 171–4. DOI:10.1016/0014-5793(94)00951-1. PMID:7925969.
- Wick M، Bürger C، Brüsselbach S، وآخرون (1994). "A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence". J. Biol. Chem. ج. 269 ع. 29: 18953–60. PMID:8034652.
- Silbiger SM، Jacobsen VL، Cupples RL، Koski RA (1994). "Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family". Gene. ج. 141 ع. 2: 293–7. DOI:10.1016/0378-1119(94)90588-6. PMID:8163205.
- Uría JA، Ferrando AA، Velasco G، وآخرون (1994). "Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family". Cancer Res. ج. 54 ع. 8: 2091–4. PMID:8174111.
- Byrne JA، Tomasetto C، Rouyer N، وآخرون (1996). "The tissue inhibitor of metalloproteinases-3 gene in breast carcinoma: identification of multiple polyadenylation sites and a stromal pattern of expression". Mol. Med. ج. 1 ع. 4: 418–27. PMC:2229996. PMID:8521299.
- Andersson B، Wentland MA، Ricafrente JY، وآخرون (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. ج. 236 ع. 1: 107–13. DOI:10.1006/abio.1996.0138. PMID:8619474.
- Felbor U، Stöhr H، Amann T، وآخرون (1996). "A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features". Hum. Mol. Genet. ج. 4 ع. 12: 2415–6. DOI:10.1093/hmg/4.12.2415. PMID:8634721.
- Carrero-Valenzuela RD، Klein ML، Weleber RG، وآخرون (1996). "Sorsby fundus dystrophy. A family with the Ser181Cys mutation of the tissue inhibitor of metalloproteinases 3". Arch. Ophthalmol. ج. 114 ع. 6: 737–8. DOI:10.1001/archopht.1996.01100130729016. PMID:8639088.
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