RRAS
RRAS (RAS related) هوَ بروتين يُشَفر بواسطة جين RRAS في الإنسان.[1][2]
الوظيفة
المراجع
- "Entrez Gene: RRAS related RAS viral (r-ras) oncogene homolog". مؤرشف من الأصل في 2010-12-05.
- Lowe DG، Capon DJ، Delwart E، Sakaguchi AY، Naylor SL، Goeddel DV (فبراير 1987). "Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes". Cell. ج. 48 ع. 1: 137–46. DOI:10.1016/0092-8674(87)90364-3. PMID:3098437.
قراءة متعمقة
- Carboni JM، Yan N، Cox AD، Bustelo X، Graham SM، Lynch MJ، Weinmann R، Seizinger BR، Der CJ، Barbacid M (1995). "Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation". Oncogene. ج. 10 ع. 10: 1905–13. PMID:7761092.
- Spaargaren M، Bischoff JR (1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. ج. 91 ع. 26: 12609–13. DOI:10.1073/pnas.91.26.12609. PMC:45488. PMID:7809086.
- Fernandez-Sarabia MJ، Bischoff JR (1993). "Bcl-2 associates with the ras-related protein R-ras p23". Nature. ج. 366 ع. 6452: 274–5. DOI:10.1038/366274a0. PMID:8232588.
- Linnemann T، Geyer M، Jaitner BK، Block C، Kalbitzer HR، Wittinghofer A، Herrmann C (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". J. Biol. Chem. ج. 274 ع. 19: 13556–62. DOI:10.1074/jbc.274.19.13556. PMID:10224125.
- Choy E، Chiu VK، Silletti J، Feoktistov M، Morimoto T، Michaelson D، Ivanov IE، Philips MR (1999). "Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi". Cell. ج. 98 ع. 1: 69–80. DOI:10.1016/S0092-8674(00)80607-8. PMID:10412982.
- Zou JX، Wang B، Kalo MS، Zisch AH، Pasquale EB، Ruoslahti E (1999). "An Eph receptor regulates integrin activity through R-Ras". Proc. Natl. Acad. Sci. U.S.A. ج. 96 ع. 24: 13813–8. DOI:10.1073/pnas.96.24.13813. PMC:24147. PMID:10570155.
- Wang B، Zou JX، Ek-Rylander B، Ruoslahti E (2000). "R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras". J. Biol. Chem. ج. 275 ع. 7: 5222–7. DOI:10.1074/jbc.275.7.5222. PMID:10671570.
- Suzuki J، Kaziro Y، Koide H (2000). "Positive regulation of skeletal myogenesis by R-Ras". Oncogene. ج. 19 ع. 9: 1138–46. DOI:10.1038/sj.onc.1203402. PMID:10713701.
- Ohba Y، Mochizuki N، Yamashita S، Chan AM، Schrader JW، Hattori S، Nagashima K، Matsuda M (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3". J. Biol. Chem. ج. 275 ع. 26: 20020–6. DOI:10.1074/jbc.M000981200. PMID:10777492.
- Yuryev A، Ono M، Goff SA، Macaluso F، Wennogle LP (2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. ج. 20 ع. 13: 4870–8. DOI:10.1128/MCB.20.13.4870-4878.2000. PMC:85938. PMID:10848612.
- Oertli B، Han J، Marte BM، Sethi T، Downward J، Ginsberg M، Hughes PE (2000). "The effector loop and prenylation site of R-Ras are involved in the regulation of integrin function". Oncogene. ج. 19 ع. 43: 4961–9. DOI:10.1038/sj.onc.1203876. PMID:11042683.
- Tian X، Feig LA (2001). "Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors". J. Biol. Chem. ج. 276 ع. 50: 47248–56. DOI:10.1074/jbc.M107407200. PMID:11560935.
- Ortiz-Vega S، Khokhlatchev A، Nedwidek M، Zhang XF، Dammann R، Pfeifer GP، Avruch J (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. ج. 21 ع. 9: 1381–90. DOI:10.1038/sj.onc.1205192. PMID:11857081.
- Yu Y، Feig LA (2002). "Involvement of R-Ras and Ral GTPases in estrogen-independent proliferation of breast cancer cells". Oncogene. ج. 21 ع. 49: 7557–68. DOI:10.1038/sj.onc.1205961. PMID:12386818.
- Kwong L، Wozniak MA، Collins AS، Wilson SD، Keely PJ (2003). "R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins". Mol. Cell. Biol. ج. 23 ع. 3: 933–49. DOI:10.1128/MCB.23.3.933-949.2003. PMC:140691. PMID:12529399.
- Rincón-Arano H، Rosales R، Mora N، Rodriguez-Castañeda A، Rosales C (2003). "R-Ras promotes tumor growth of cervical epithelial cells". Cancer. ج. 97 ع. 3: 575–85. DOI:10.1002/cncr.11093. PMID:12548599.
- Furuhjelm J، Peränen J (2003). "The C-terminal end of R-Ras contains a focal adhesion targeting signal". J. Cell Sci. ج. 116 ع. Pt 18: 3729–38. DOI:10.1242/jcs.00689. PMID:12890755.
- Mitin NY، Ramocki MB، Zullo AJ، Der CJ، Konieczny SF، Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. ج. 279 ع. 21: 22353–61. DOI:10.1074/jbc.M312867200. PMID:15031288.
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بوابة علم الأحياء الخلوي والجزيئي
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