RAC3

Rac family small GTPase 3
المعرفات
الأسماء المستعارة	RAC3, ras-related C3 botulinum toxin substrate 3, p21-Rac3, ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), rho family, small GTP binding protein Rac3
معرفات خارجية
أورثولوج
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	ويكي بيانات
اعرض/عدّل إنسان

RAC3‏ (Rac family small GTPase 3) هوَ بروتين يُشَفر بواسطة جين RAC3 في الإنسان.[1][1]

الوظيفة

المراجع

"Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

Didsbury J، Weber RF، Bokoch GM، وآخرون (1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates". J. Biol. Chem. ج. 264 ع. 28: 16378–82. PMID:2674130.
Bonaldo MF، Lennon G، Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. ج. 6 ع. 9: 791–806. DOI:10.1101/gr.6.9.791. PMID:8889548.
Haataja L، Groffen J، Heisterkamp N (1997). "Characterization of RAC3, a novel member of the Rho family". J. Biol. Chem. ج. 272 ع. 33: 20384–8. DOI:10.1074/jbc.272.33.20384. PMID:9252344.
Courjal F، Chuchana P، Theillet C، Fort P (1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. ج. 44 ع. 2: 242–6. DOI:10.1006/geno.1997.4871. PMID:9299243.
Mira JP، Benard V، Groffen J، وآخرون (2000). "Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 1: 185–9. Bibcode:2000PNAS...97..185M. DOI:10.1073/pnas.97.1.185. PMC:26637. PMID:10618392.
Soutoglou E، Papafotiou G، Katrakili N، Talianidis I (2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. ج. 275 ع. 17: 12515–20. DOI:10.1074/jbc.275.17.12515. PMID:10777539.
Morris CM، Haataja L، McDonald M، وآخرون (2000). "The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours". Cytogenet. Cell Genet. ج. 89 ع. 1–2: 18–23. DOI:10.1159/000015583. PMID:10894930.
Gnanapragasam VJ، Leung HY، Pulimood AS، وآخرون (2002). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer. ج. 85 ع. 12: 1928–36. DOI:10.1054/bjoc.2001.2179. PMC:2364015. PMID:11747336.
Haataja L، Kaartinen V، Groffen J، Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. ج. 277 ع. 10: 8321–8. DOI:10.1074/jbc.M105363200. PMID:11756406.
De Langhe S، Haataja L، Senadheera D، وآخرون (2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int. J. Mol. Med. ج. 9 ع. 5: 451–9. DOI:10.3892/ijmm.9.5.451. PMID:11956649.
Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
Zhang A، Yeung PL، Li CW، وآخرون (2004). "Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators". J. Biol. Chem. ج. 279 ع. 32: 33799–805. DOI:10.1074/jbc.M403997200. PMID:15184363.
Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
Hwang SL، Chang JH، Cheng TS، وآخرون (2006). "Expression of Rac3 in human brain tumors". Journal of Clinical Neuroscience. ج. 12 ع. 5: 571–4. DOI:10.1016/j.jocn.2004.08.013. PMID:15993075.
Chan AY، Coniglio SJ، Chuang YY، وآخرون (2005). "Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion". Oncogene. ج. 24 ع. 53: 7821–9. DOI:10.1038/sj.onc.1208909. PMID:16027728.
Rual JF، Venkatesan K، Hao T، وآخرون (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. ج. 437 ع. 7062: 1173–8. Bibcode:2005Natur.437.1173R. DOI:10.1038/nature04209. PMID:16189514.
Baugher PJ، Krishnamoorthy L، Price JE، Dharmawardhane SF (2006). "Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells". Breast Cancer Res. ج. 7 ع. 6: R965–74. DOI:10.1186/bcr1329. PMC:1410764. PMID:16280046.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
Watabe-Uchida M، John KA، Janas JA، وآخرون (2006). "The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18". Neuron. ج. 51 ع. 6: 727–39. DOI:10.1016/j.neuron.2006.07.020. PMID:16982419.
Hajdo-Milasinović A، Ellenbroek SI، van Es S، وآخرون (2007). "Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells". J. Cell Sci. ج. 120 ع. Pt 4: 555–66. DOI:10.1242/jcs.03364. PMID:17244648.

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[entrez-1] "Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)". مؤرشف من الأصل في 2010-12-05.