PTF1A
PTF1A (Pancreas associated transcription factor 1a) هوَ بروتين يُشَفر بواسطة جين PTF1A في الإنسان.[1][2]
الوظيفة
المراجع
- "Entrez Gene: PTF1A pancreas specific transcription factor, 1a". مؤرشف من الأصل في 2010-03-08.
- Knöfler M، Krapp A، Hagenbüchle O، Wellauer PK (سبتمبر 1996). "Constitutive expression of the gene for the cell-specific p48 DNA-binding subunit of pancreas transcription factor 1 in cultured cells is under control of binding sites for transcription factors Sp1 and alphaCbf". The Journal of Biological Chemistry. ج. 271 ع. 36: 21993–2002. DOI:10.1074/jbc.271.36.21993. PMID:8703005.
قراءة متعمقة
- Sommer L، Hagenbüchle O، Wellauer PK، Strubin M (نوفمبر 1991). "Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence". Cell. ج. 67 ع. 5: 987–94. DOI:10.1016/0092-8674(91)90371-5. PMID:1720355.
- Roux E، Strubin M، Hagenbüchle O، Wellauer PK (أكتوبر 1989). "The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA". Genes & Development. ج. 3 ع. 10: 1613–24. DOI:10.1101/gad.3.10.1613. PMID:2612907.
- Krapp A، Knöfler M، Frutiger S، Hughes GJ، Hagenbüchle O، Wellauer PK (أغسطس 1996). "The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein". The EMBO Journal. ج. 15 ع. 16: 4317–29. PMC:452157. PMID:8861960.
- Krapp A، Knöfler M، Ledermann B، Bürki K، Berney C، Zoerkler N، Hagenbüchle O، Wellauer PK (ديسمبر 1998). "The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas". Genes & Development. ج. 12 ع. 23: 3752–63. DOI:10.1101/gad.12.23.3752. PMC:317250. PMID:9851981.
- Adell T، Gómez-Cuadrado A، Skoudy A، Pettengill OS، Longnecker DS، Real FX (مارس 2000). "Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells". Cell Growth & Differentiation. ج. 11 ع. 3: 137–47. PMID:10768861.
- Kawaguchi Y، Cooper B، Gannon M، Ray M، MacDonald RJ، Wright CV (سبتمبر 2002). "The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors". Nature Genetics. ج. 32 ع. 1: 128–34. DOI:10.1038/ng959. PMID:12185368.
- McLellan AS، Langlands K، Kealey T (ديسمبر 2002). "Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening". Gene Expression Patterns. ج. 2 ع. 3–4: 329–35. DOI:10.1016/S0925-4773(02)00390-8. PMID:12617822.
- Sellick GS، Barker KT، Stolte-Dijkstra I، Fleischmann C، Coleman RJ، Garrett C، Gloyn AL، Edghill EL، Hattersley AT، Wellauer PK، Goodwin G، Houlston RS (ديسمبر 2004). "Mutations in PTF1A cause pancreatic and cerebellar agenesis". Nature Genetics. ج. 36 ع. 12: 1301–5. DOI:10.1038/ng1475. PMID:15543146.
- Beres TM، Masui T، Swift GH، Shi L، Henke RM، MacDonald RJ (يناير 2006). "PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L". Molecular and Cellular Biology. ج. 26 ع. 1: 117–30. DOI:10.1128/MCB.26.1.117-130.2006. PMC:1317634. PMID:16354684.
- Yamada M، Terao M، Terashima T، Fujiyama T، Kawaguchi Y، Nabeshima Y، Hoshino M (أكتوبر 2007). "Origin of climbing fiber neurons and their developmental dependence on Ptf1a". The Journal of Neuroscience. ج. 27 ع. 41: 10924–34. DOI:10.1523/JNEUROSCI.1423-07.2007. PMID:17928434.
بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
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