PARD3
PARD3 (Par-3 family cell polarity regulator) هوَ بروتين يُشَفر بواسطة جين PARD3 في الإنسان.[1][2]
الوظيفة
المراجع
- Joberty G، Petersen C، Gao L، Macara IG (أكتوبر 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42". Nat Cell Biol. ج. 2 ع. 8: 531–9. DOI:10.1038/35019573. PMID:10934474.
- "Entrez Gene: PARD3 par-3 partitioning defective 3 homolog (C. elegans)". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة
- Johansson A، Driessens M، Aspenström P (2000). "The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1". J. Cell Sci. ج. 113 ع. 18: 3267–75. PMID:10954424.
- Eichmuller S، Usener D، Dummer R، Stein A، Thiel D، Schadendorf D (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. ج. 98 ع. 2: 629–34. DOI:10.1073/pnas.021386498. PMC:14639. PMID:11149944.
- Suzuki A، Yamanaka T، Hirose T، Manabe N، Mizuno K، Shimizu M، Akimoto K، Izumi Y، Ohnishi T، Ohno S (2001). "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures". J. Cell Biol. ج. 152 ع. 6: 1183–96. DOI:10.1083/jcb.152.6.1183. PMC:2199212. PMID:11257119.
- Noda Y، Takeya R، Ohno S، Naito S، Ito T، Sumimoto H (2001). "Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.". Genes Cells. ج. 6 ع. 2: 107–19. DOI:10.1046/j.1365-2443.2001.00404.x. PMID:11260256.
- Ebnet K، Suzuki A، Horikoshi Y، Hirose T، Meyer Zu Brickwedde MK، Ohno S، Vestweber D (2001). "The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)". EMBO J. ج. 20 ع. 14: 3738–48. DOI:10.1093/emboj/20.14.3738. PMC:125258. PMID:11447115.
- Fang CM، Xu YH (2002). "Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas". Cell Res. ج. 11 ع. 3: 223–9. DOI:10.1038/sj.cr.7290090. PMID:11642408.
- Gao L، Macara IG، Joberty G (2003). "Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties". Gene. ج. 294 ع. 1–2: 99–107. DOI:10.1016/S0378-1119(02)00681-9. PMID:12234671.
- Kohjima M، Noda Y، Takeya R، Saito N، Takeuchi K، Sumimoto H (2003). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochem. Biophys. Res. Commun. ج. 299 ع. 4: 641–6. DOI:10.1016/S0006-291X(02)02698-0. PMID:12459187.
- Takekuni K، Ikeda W، Fujito T، Morimoto K، Takeuchi M، Monden M، Takai Y (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. ج. 278 ع. 8: 5497–500. DOI:10.1074/jbc.C200707200. PMID:12515806.
- Warner DR، Pisano MM، Roberts EA، Greene RM (2003). "Identification of three novel Smad binding proteins involved in cell polarity". FEBS Lett. ج. 539 ع. 1–3: 167–73. DOI:10.1016/S0014-5793(03)00155-8. PMID:12650946.
- Brajenovic M، Joberty G، Küster B، Bouwmeester T، Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. ج. 279 ع. 13: 12804–11. DOI:10.1074/jbc.M312171200. PMID:14676191.
- Navarro-Lérida I، Martínez Moreno M، Roncal F، Gavilanes F، Albar JP، Rodríguez-Crespo I (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. ج. 4 ع. 2: 339–46. DOI:10.1002/pmic.200300528. PMID:14760703.
- Brill LM، Salomon AR، Ficarro SB، Mukherji M، Stettler-Gill M، Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. ج. 76 ع. 10: 2763–72. DOI:10.1021/ac035352d. PMID:15144186.
- Liu XF، Ishida H، Raziuddin R، Miki T (2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. ج. 24 ع. 15: 6665–75. DOI:10.1128/MCB.24.15.6665-6675.2004. PMC:444862. PMID:15254234.
- Beausoleil SA، Jedrychowski M، Schwartz D، Elias JE، Villén J، Li J، Cohn MA، Cantley LC، Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. ج. 101 ع. 33: 12130–5. DOI:10.1073/pnas.0404720101. PMC:514446. PMID:15302935.
- Jin J، Smith FD، Stark C، Wells CD، Fawcett JP، Kulkarni S، Metalnikov P، O'Donnell P، Taylor P، Taylor L، Zougman A، Woodgett JR، Langeberg LK، Scott JD، Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. ج. 14 ع. 16: 1436–50. DOI:10.1016/j.cub.2004.07.051. PMID:15324660.
- بوابة الكيمياء الحيوية
- بوابة علم الأحياء الخلوي والجزيئي
- بوابة طب
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