NFATC1
NFATC1 (Nuclear factor of-activated T-cells, cytoplasmic 1) هوَ بروتين يُشَفر بواسطة جين NFATC1 في الإنسان.[1]
الوظيفة
المراجع
- Northrop JP، Ho SN، Chen L، Thomas DJ، Timmerman LA، Nolan GP، Admon A، Crabtree GR (يونيو 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. ج. 369 ع. 6480: 497–502. DOI:10.1038/369497a0. PMID:8202141.
قراءة متعمقة
- Rao A، Luo C، Hogan PG (1997). "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology. ج. 15: 707–47. DOI:10.1146/annurev.immunol.15.1.707. PMID:9143705.
- Crabtree GR (مارس 1999). "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell. ج. 96 ع. 5: 611–4. DOI:10.1016/S0092-8674(00)80571-1. PMID:10089876.
- Horsley V، Pavlath GK (مارس 2002). "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology. ج. 156 ع. 5: 771–4. DOI:10.1083/jcb.200111073. PMC:2173310. PMID:11877454.
- Tolstrup M، Ostergaard L، Laursen AL، Pedersen SF، Duch M (أبريل 2004). "HIV/SIV escape from immune surveillance: focus on Nef". Current HIV Research. ج. 2 ع. 2: 141–51. DOI:10.2174/1570162043484924. PMID:15078178.
- Li X، Ho SN، Luna J، Giacalone J، Thomas DJ، Timmerman LA، Crabtree GR، Francke U (1995). "Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp". Cytogenetics and Cell Genetics. ج. 68 ع. 3–4: 185–91. DOI:10.1159/000133910. PMID:7842733.
- Jabado N، Le Deist F، Fisher A، Hivroz C (نوفمبر 1994). "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology. ج. 24 ع. 11: 2646–52. DOI:10.1002/eji.1830241112. PMID:7957556.
- Vacca A، Farina M، Maroder M، Alesse E، Screpanti I، Frati L، Gulino A (نوفمبر 1994). "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications. ج. 205 ع. 1: 467–74. DOI:10.1006/bbrc.1994.2689. PMID:7999066.
- Park J، Takeuchi A، Sharma S (أغسطس 1996). "Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc". The Journal of Biological Chemistry. ج. 271 ع. 34: 20914–21. DOI:10.1074/jbc.271.34.20914. PMID:8702849.
- Di Somma MM، Majolini MB، Burastero SE، Telford JL، Baldari CT (سبتمبر 1996). "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology. ج. 26 ع. 9: 2181–8. DOI:10.1002/eji.1830260933. PMID:8814265.
- Beals CR، Sheridan CM، Turck CW، Gardner P، Crabtree GR (مارس 1997). "Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. ج. 275 ع. 5308: 1930–4. DOI:10.1126/science.275.5308.1930. PMID:9072970.
- Kinoshita S، Su L، Amano M، Timmerman LA، Kaneshima H، Nolan GP (مارس 1997). "The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells". Immunity. ج. 6 ع. 3: 235–44. DOI:10.1016/S1074-7613(00)80326-X. PMID:9075924.
- Zhou P، Sun LJ، Dötsch V، Wagner G، Verdine GL (مارس 1998). "Solution structure of the core NFATC1/DNA complex". Cell. ج. 92 ع. 5: 687–96. DOI:10.1016/S0092-8674(00)81136-8. PMID:9506523.
- Kinoshita S، Chen BK، Kaneshima H، Nolan GP (نوفمبر 1998). "Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells". Cell. ج. 95 ع. 5: 595–604. DOI:10.1016/S0092-8674(00)81630-X. PMID:9845362.
- Chuvpilo S، Zimmer M، Kerstan A، Glöckner J، Avots A، Escher C، Fischer C، Inashkina I، Jankevics E، Berberich-Siebelt F، Schmitt E، Serfling E (فبراير 1999). "Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells". Immunity. ج. 10 ع. 2: 261–9. DOI:10.1016/S1074-7613(00)80026-6. PMID:10072078.
- Chuvpilo S، Avots A، Berberich-Siebelt F، Glöckner J، Fischer C، Kerstan A، Escher C، Inashkina I، Hlubek F، Jankevics E، Brabletz T، Serfling E (يونيو 1999). "Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes". Journal of Immunology. ج. 162 ع. 12: 7294–301. PMID:10358178.
- Wang JK، Kiyokawa E، Verdin E، Trono D (يناير 2000). "The Nef protein of HIV-1 associates with rafts and primes T cells for activation". Proceedings of the National Academy of Sciences of the United States of America. ج. 97 ع. 1: 394–9. DOI:10.1073/pnas.97.1.394. PMC:26674. PMID:10618429.
- Porter CM، Havens MA، Clipstone NA (فبراير 2000). "Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization". The Journal of Biological Chemistry. ج. 275 ع. 5: 3543–51. DOI:10.1074/jbc.275.5.3543. PMID:10652349.
- بوابة طب
- بوابة الكيمياء الحيوية
- بوابة علم الأحياء الخلوي والجزيئي
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