ID2

ID2
التراكيب المتوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	4AYA
المعرفات
الأسماء المستعارة	ID2, GIG8, A, H, bHLHb26, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 600386 MGI: MGI:96397 HomoloGene: 1632 GeneCards: 3398
علم الوجود الجيني
الوظيفة الجزيئية	• protein dimerization activity; • transmembrane transporter binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • ‏GO:0001131، ‏GO:0001151، ‏GO:0001130، ‏GO:0001204 DNA-binding transcription factor activity; • transcription factor binding;
المكونات الخلوية	• نواة; • عصارة خلوية; • سيتوبلازم; • ‏GO:0009327 protein-containing complex;
العمليات الحيوية	• regulation of G1/S transition of mitotic cell cycle; • rhythmic process; • negative regulation of DNA-binding transcription factor activity; • ‏GO:0009373 ضبط نسخ الدنا; • positive regulation of transcription involved in G1/S transition of mitotic cell cycle; • نمو متعدد الخلايا; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • نسخ الدنا; • ‏GO:1901227 negative regulation of transcription by RNA polymerase II; • metanephros development; • natural killer cell differentiation; • thigmotaxis; • leukocyte differentiation; • membranous septum morphogenesis; • bundle of His development; • نماء القلب; • نظم يوماوي; • adult locomotory behavior; • entrainment of circadian clock; • ‏GO:1901313 positive regulation of gene expression; • negative regulation of gene expression; • oligodendrocyte development; • regulation of lipid metabolic process; • olfactory bulb development; • circadian regulation of gene expression; • mammary gland epithelial cell proliferation; • regulation of circadian rhythm; • entrainment of circadian clock by photoperiod; • enucleate erythrocyte differentiation; • negative regulation of DNA binding; • locomotor rhythm; • negative regulation of B cell differentiation; • positive regulation of fat cell differentiation; • positive regulation of erythrocyte differentiation; • positive regulation of macrophage differentiation; • negative regulation of neuron differentiation; • negative regulation of osteoblast differentiation; • positive regulation of blood pressure; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • cell development; • cell maturation; • Peyer's patch development; • embryonic digestive tract morphogenesis; • positive regulation of smooth muscle cell proliferation; • neuron fate commitment; • cell morphogenesis involved in neuron differentiation; • positive regulation of astrocyte differentiation; • negative regulation of oligodendrocyte differentiation; • adipose tissue development; • mammary gland alveolus development; • epithelial cell differentiation involved in mammary gland alveolus development; • endodermal digestive tract morphogenesis; • cellular response to lithium ion; • شيخوخة خلوية; • negative regulation of neural precursor cell proliferation; • neuron differentiation; • regulation of cell cycle;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
أورثولوج
	Q02363
	P41136
	NM_002166
	NM_010496
	NP_002157
	NP_034626
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

ID2‏ (Inhibitor of DNA binding 2) هوَ بروتين يُشَفر بواسطة جين ID2 في الإنسان.[1]

الوظيفة

المراجع

Hara E، Yamaguchi T، Nojima H، Ide T، Campisi J، Okayama H، Oda K (فبراير 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". J Biol Chem. ج. 269 ع. 3: 2139–45. PMID:8294468.

قراءة متعمقة

Biggs J، Murphy EV، Israel MA (1992). "A human Id-like helix-loop-helix protein expressed during early development". Proc. Natl. Acad. Sci. U.S.A. ج. 89 ع. 4: 1512–6. DOI:10.1073/pnas.89.4.1512. PMC:48481. PMID:1741406.
Iavarone A، Garg P، Lasorella A، Hsu J، Israel MA (1994). "The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein". Genes Dev. ج. 8 ع. 11: 1270–84. DOI:10.1101/gad.8.11.1270. PMID:7926730.
Maruyama K، Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. ج. 138 ع. 1–2: 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID:8125298.
Kurabayashi M، Jeyaseelan R، Kedes L (1993). "Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2". Gene. ج. 133 ع. 2: 305–6. DOI:10.1016/0378-1119(93)90658-P. PMID:8224921.
Mathew S، Chen W، Murty VV، Benezra R، Chaganti RS (1996). "Chromosomal assignment of human ID1 and ID2 genes". Genomics. ج. 30 ع. 2: 385–7. DOI:10.1006/geno.1995.0037. PMID:8586447.
Lasorella A، Iavarone A، Israel MA (1996). "Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins". Mol. Cell. Biol. ج. 16 ع. 6: 2570–8. PMC:231247. PMID:8649364.
Hara E، Hall M، Peters G (1997). "Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors". EMBO J. ج. 16 ع. 2: 332–42. DOI:10.1093/emboj/16.2.332. PMC:1169639. PMID:9029153.
Langlands K، Yin X، Anand G، Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. ج. 272 ع. 32: 19785–93. DOI:10.1074/jbc.272.32.19785. PMID:9242638.
Suzuki Y، Yoshitomo-Nakagawa K، Maruyama K، Suyama A، Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. ج. 200 ع. 1–2: 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID:9373149.
Yates PR، Atherton GT، Deed RW، Norton JD، Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. ج. 18 ع. 4: 968–76. DOI:10.1093/emboj/18.4.968. PMC:1171189. PMID:10022839.
Yokota Y، Mansouri A، Mori S، Sugawara S، Adachi S، Nishikawa S، Gruss P (1999). "Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2". Nature. ج. 397 ع. 6721: 702–6. DOI:10.1038/17812. PMID:10067894.
Law SF، Zhang YZ، Fashena SJ، Toby G، Estojak J، Golemis EA (1999). "Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain". Exp. Cell Res. ج. 252 ع. 1: 224–35. DOI:10.1006/excr.1999.4609. PMID:10502414.
Moldes M، Boizard M، Liepvre XL، Fève B، Dugail I، Pairault J (2000). "Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes". Biochem. J. 344 Pt 3 ع. Pt 3: 873–80. DOI:10.1042/0264-6021:3440873. PMC:1220711. PMID:10585876.
Liu J، Shi W، Warburton D (2000). "A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function". Biochem. Biophys. Res. Commun. ج. 273 ع. 3: 1042–7. DOI:10.1006/bbrc.2000.3055. PMID:10891368.
Lasorella A، Noseda M، Beyna M، Yokota Y، Iavarone A (2000). "Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins". Nature. ج. 407 ع. 6804: 592–8. DOI:10.1038/35036504. PMID:11034201.
Roberts EC، Deed RW، Inoue T، Norton JD، Sharrocks AD (2001). "Id Helix-Loop-Helix Proteins Antagonize Pax Transcription Factor Activity by Inhibiting DNA Binding". Mol. Cell. Biol. ج. 21 ع. 2: 524–33. DOI:10.1128/MCB.21.2.524-533.2001. PMC:86614. PMID:11134340.
Wang S، Sdrulla A، Johnson JE، Yokota Y، Barres BA (2001). "A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development". Neuron. ج. 29 ع. 3: 603–14. DOI:10.1016/S0896-6273(01)00237-9. PMID:11301021.
Wong J، Funes-Duran M، Ahlberg J، Round J، O'Connell R، Miller R، Chen E، Richmond PA، Vierra CA (2001). "Characterization of a basic helix-loop-helix protein, ABF-1: nuclear localization, transcriptional properties, and interaction with Id-2". DNA Cell Biol. ج. 20 ع. 8: 465–71. DOI:10.1089/104454901316976091. PMID:11560778.
Suzuki H، Fukunishi Y، Kagawa I، Saito R، Oda H، Endo T، Kondo S، Bono H، Okazaki Y، Hayashizaki Y (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. ج. 11 ع. 10: 1758–65. DOI:10.1101/gr.180101. PMC:311163. PMID:11591653.

بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
بوابة الكيمياء الحيوية

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[pmid8294468-1] Hara E، Yamaguchi T، Nojima H، Ide T، Campisi J، Okayama H، Oda K (فبراير 1994). "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". J Biol Chem. ج. 269 ع. 3: 2139–45. PMID:8294468.

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 600386
المعرفات الخارجية	Ensembl Transcript ID: ENST00000396290 نظام اللغة الطبية الموحدة (UMLS CUI): C1334077