FGF7

FGF7
المعرفات
الأسماء المستعارة	FGF7, HBGF-7, KGF, fibroblast growth factor 7
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 148180 MGI: MGI:95521 HomoloGene: 7316 GeneCards: 2252
علم الوجود الجيني
الوظيفة الجزيئية	• heparin binding; • fibroblast growth factor receptor binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • chemoattractant activity; • growth factor activity; • 1-phosphatidylinositol-3-kinase activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
المكونات الخلوية	• جهاز غولجي; • منطقة خارج الخلية;
العمليات الحيوية	• actin cytoskeleton reorganization; • mesenchymal cell proliferation; • positive regulation of keratinocyte proliferation; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • secretion by lung epithelial cell involved in lung growth; • positive regulation of epithelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • MAPK cascade; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • fibroblast growth factor receptor signaling pathway; • positive regulation of keratinocyte migration; • protein localization to cell surface; • response to wounding; • ضبط زيادي للتكاثر الخلوي; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • hair follicle morphogenesis; • positive chemotaxis; • positive regulation of cell division; • ‏GO:0072468 توصيل الإشارة; • branching involved in salivary gland morphogenesis; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P21781
	P36363
	NM_002009
	NM_008008
	NP_002000
	NP_032034
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FGF7‏ (Fibroblast growth factor 7) هوَ بروتين يُشَفر بواسطة جين FGF7 في الإنسان.[1][2][3]

الوظيفة

المراجع

"Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)". مؤرشف من الأصل في 2010-12-05.
Kelley MJ، Pech M، Seuanez HN، Rubin JS، O'Brien SJ، Aaronson SA (أكتوبر 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. ج. 89 ع. 19: 9287–91. DOI:10.1073/pnas.89.19.9287. PMC:50111. PMID:1409637.
Mattei MG، deLapeyrière O، Bresnick J، Dickson C، Birnbaum D، Mason I (مارس 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. ج. 6 ع. 3: 196–7. DOI:10.1007/BF00293012. PMID:7749227.

قراءة متعمقة

Beer HD، Gassmann MG، Munz B، Steiling H، Engelhardt F، Bleuel K، Werner S (ديسمبر 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings. ج. 5 ع. 1: 34–9. DOI:10.1046/j.1087-0024.2000.00009.x. PMID:11147673.
Ware LB، Matthay MA (مايو 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology. ج. 282 ع. 5: L924–40. DOI:10.1152/ajplung.00439.2001. PMID:11943656.
Finch PW، Rubin JS (2004). "Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair". Advances in Cancer Research. Advances in Cancer Research. ج. 91: 69–136. DOI:10.1016/S0065-230X(04)91003-2. ISBN:978-0-12-006691-9. PMID:15327889. مؤرشف من الأصل في 2019-12-07.
Ishibashi T، Bottaro DP، Chan A، Miki T، Aaronson SA (ديسمبر 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America. ج. 89 ع. 24: 12170–4. DOI:10.1073/pnas.89.24.12170. PMC:50720. PMID:1281549.
Aaronson SA، Bottaro DP، Miki T، Ron D، Finch PW، Fleming TP، Ahn J، Taylor WG، Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. ج. 638: 62–77. DOI:10.1111/j.1749-6632.1991.tb49018.x. PMID:1664700.
Finch PW، Rubin JS، Miki T، Ron D، Aaronson SA (أغسطس 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science. ج. 245 ع. 4919: 752–5. DOI:10.1126/science.2475908. PMID:2475908.
Rubin JS، Osada H، Finch PW، Taylor WG، Rudikoff S، Aaronson SA (فبراير 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. ج. 86 ع. 3: 802–6. DOI:10.1073/pnas.86.3.802. PMC:286565. PMID:2915979.
Ron D، Reich R، Chedid M، Lengel C، Cohen OE، Chan AM، Neufeld G، Miki T، Tronick SR (مارس 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry. ج. 268 ع. 8: 5388–94. PMID:7680645.
Yan G، Fukabori Y، McBride G، Nikolaropolous S، McKeehan WL (أغسطس 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology. ج. 13 ع. 8: 4513–22. PMC:360063. PMID:7687739.
Werner S، Smola H، Liao X، Longaker MT، Krieg T، Hofschneider PH، Williams LT (نوفمبر 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. ج. 266 ع. 5186: 819–22. DOI:10.1126/science.7973639. PMID:7973639.
Wilson SE، Walker JW، Chwang EL، He YG (يوليو 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. ج. 34 ع. 8: 2544–61. PMID:8392040.
Guo L، Degenstein L، Fuchs E (يناير 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. ج. 10 ع. 2: 165–75. DOI:10.1101/gad.10.2.165. PMID:8566750.
Ornitz DM، Xu J، Colvin JS، McEwen DG، MacArthur CA، Coulier F، Gao G، Goldfarb M (يونيو 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. ج. 271 ع. 25: 15292–7. DOI:10.1074/jbc.271.25.15292. PMID:8663044.
Post M، Souza P، Liu J، Tseu I، Wang J، Kuliszewski M، Tanswell AK (أكتوبر 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. ج. 122 ع. 10: 3107–15. PMID:8898224.
Zimonjic DB، Kelley MJ، Rubin JS، Aaronson SA، Popescu NC (أكتوبر 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America. ج. 94 ع. 21: 11461–5. DOI:10.1073/pnas.94.21.11461. PMC:23506. PMID:9326632.
Winkles JA، Alberts GF، Chedid M، Taylor WG، DeMartino S، Rubin JS (ديسمبر 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. ج. 173 ع. 3: 380–6. DOI:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID:9369951.
Ishibashi T، Tanaka T، Nibu K، Ishimoto S، Kaga K (أكتوبر 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. ج. 107 ع. 10 Pt 1: 885–90. PMID:9794620.
Mongiat M، Taylor K، Otto J، Aho S، Uitto J، Whitelock JM، Iozzo RV (مارس 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. ج. 275 ع. 10: 7095–100. DOI:10.1074/jbc.275.10.7095. PMID:10702276.

بوابة الكيمياء الحيوية
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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[entrez-1] "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)". مؤرشف من الأصل في 2010-12-05.

[pmid1409637-2] Kelley MJ، Pech M، Seuanez HN، Rubin JS، O'Brien SJ، Aaronson SA (أكتوبر 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. ج. 89 ع. 19: 9287–91. DOI:10.1073/pnas.89.19.9287. PMC:50111. PMID:1409637.

[pmid7749227-3] Mattei MG، deLapeyrière O، Bresnick J، Dickson C، Birnbaum D، Mason I (مارس 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. ج. 6 ع. 3: 196–7. DOI:10.1007/BF00293012. PMID:7749227.

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 148180
المعرفات الخارجية	Ensembl Transcript ID: ENST00000560979 نظام اللغة الطبية الموحدة (UMLS CUI): C0919507