FCN2
FCN2 (Ficolin 2) هوَ بروتين يُشَفر بواسطة جين FCN2 في الإنسان.[1][2]
الوظيفة
المراجع
- "Entrez Gene: FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)". مؤرشف من الأصل في 2010-12-05.
- Endo Y، Sato Y، Matsushita M، Fujita T (فبراير 1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics. ج. 36 ع. 3: 515–21. DOI:10.1006/geno.1996.0497. PMID:8884275.
قراءة متعمقة
- Lu J، Le Y (1999). "Ficolins and the fibrinogen-like domain". Immunobiology. ج. 199 ع. 2: 190–9. DOI:10.1016/s0171-2985(98)80026-0. PMID:9777405.
- Edgar PF (1996). "Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins". FEBS Lett. ج. 375 ع. 1–2: 159–61. DOI:10.1016/0014-5793(95)01205-S. PMID:7498469.
- Matsushita M، Endo Y، Taira S، وآخرون (1996). "A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin". J. Biol. Chem. ج. 271 ع. 5: 2448–54. DOI:10.1074/jbc.271.5.2448. PMID:8576206.
- Le Y، Tan SM، Lee SH، وآخرون (1997). "Purification and binding properties of a human ficolin-like protein". J. Immunol. Methods. ج. 204 ع. 1: 43–9. DOI:10.1016/S0022-1759(97)00029-X. PMID:9202708.
- Kilpatrick DC، Fujita T، Matsushita M (1999). "P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients". Immunol. Lett. ج. 67 ع. 2: 109–12. DOI:10.1016/S0165-2478(98)00147-3. PMID:10232391.
- Taira S، Kodama N، Matsushita M، Fujita T (2001). "Opsonic function and concentration of human serum ficolin/P35". Fukushima journal of medical science. ج. 46 ع. 1–2: 13–23. DOI:10.5387/fms.46.13. PMID:11446374.
- Cseh S، Vera L، Matsushita M، وآخرون (2003). "Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2". J. Immunol. ج. 169 ع. 10: 5735–43. DOI:10.4049/jimmunol.169.10.5735. PMID:12421953.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Ohashi T، Erickson HP (2004). "The disulfide bonding pattern in ficolin multimers". J. Biol. Chem. ج. 279 ع. 8: 6534–9. DOI:10.1074/jbc.M310555200. PMID:14660572.
- Ota T، Suzuki Y، Nishikawa T، وآخرون (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. ج. 36 ع. 1: 40–5. DOI:10.1038/ng1285. PMID:14702039.
- Lynch NJ، Roscher S، Hartung T، وآخرون (2004). "L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement". J. Immunol. ج. 172 ع. 2: 1198–202. DOI:10.4049/jimmunol.172.2.1198. PMID:14707097.
- Krarup A، Thiel S، Hansen A، وآخرون (2005). "L-ficolin is a pattern recognition molecule specific for acetyl groups". J. Biol. Chem. ج. 279 ع. 46: 47513–9. DOI:10.1074/jbc.M407161200. PMID:15331601.
- Herpers BL، Immink MM، de Jong BA، وآخرون (2006). "Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors". Mol. Immunol. ج. 43 ع. 7: 851–5. DOI:10.1016/j.molimm.2005.06.035. PMID:16076493.
- Tanio M، Kondo S، Sugio S، Kohno T (2006). "Overexpression, purification and preliminary crystallographic analysis of human M-ficolin fibrinogen-like domain". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. ج. 62 ع. Pt 7: 652–5. DOI:10.1107/S1744309106019786. PMC:2242945. PMID:16820685.
- Chen X، Katoh Y، Nakamura K، وآخرون (2006). "Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease". J. Dermatol. Sci. ج. 43 ع. 3: 201–5. DOI:10.1016/j.jdermsci.2006.05.010. PMID:16839748.
- Garlatti V، Belloy N، Martin L، وآخرون (2007). "Structural insights into the innate immune recognition specificities of L- and H-ficolins". EMBO J. ج. 26 ع. 2: 623–33. DOI:10.1038/sj.emboj.7601500. PMC:1783469. PMID:17215869.
- Chapman SJ، Vannberg FO، Khor CC، وآخرون (2007). "Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease". Mol. Immunol. ج. 44 ع. 12: 3267–70. DOI:10.1016/j.molimm.2006.04.013. PMID:17382393.
- Munthe-Fog L، Hummelshøj T، Hansen BE، وآخرون (2007). "The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels". Scand. J. Immunol. ج. 65 ع. 4: 383–92. DOI:10.1111/j.1365-3083.2007.01915.x. PMID:17386030.
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