DRAP1
DRAP1 (DR1 associated protein 1) هوَ بروتين يُشَفر بواسطة جين DRAP1 في الإنسان.[1][2][2]
الوظيفة
المراجع
- Mermelstein F، Yeung K، Cao J، Inostroza JA، Erdjument-Bromage H، Eagelson K، Landsman D، Levitt P، Tempst P، Reinberg D (مايو 1996). "Requirement of a corepressor for Dr1-mediated repression of transcription". Genes Dev. ج. 10 ع. 8: 1033–48. DOI:10.1101/gad.10.8.1033. PMID:8608938.
- "Entrez Gene: DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)". مؤرشف من الأصل في 2010-12-05.
قراءة متعمقة
- Goppelt A، Stelzer G، Lottspeich F، Meisterernst M (1996). "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains". EMBO J. ج. 15 ع. 12: 3105–16. PMC:450253. PMID:8670811.
- Yeung K، Kim S، Reinberg D (1997). "Functional dissection of a human Dr1-DRAP1 repressor complex". Mol. Cell. Biol. ج. 17 ع. 1: 36–45. PMC:231727. PMID:8972183.
- Ikeda K، Halle JP، Stelzer G، وآخرون (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Mol. Cell. Biol. ج. 18 ع. 1: 10–8. DOI:10.1128/mcb.18.1.10. PMC:121442. PMID:9418848.
- Castaño E، Gross P، Wang Z، وآخرون (2000). "The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 13: 7184–9. Bibcode:2000PNAS...97.7184C. DOI:10.1073/pnas.140202297. PMC:16520. PMID:10852970.
- Kamada K، Shu F، Chen H، وآخرون (2001). "Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex". Cell. ج. 106 ع. 1: 71–81. DOI:10.1016/S0092-8674(01)00417-2. PMID:11461703.
- Iratni R، Yan YT، Chen C، وآخرون (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. ج. 298 ع. 5600: 1996–9. Bibcode:2002Sci...298.1996I. DOI:10.1126/science.1073405. PMID:12471260.
- Denko N، Wernke-Dollries K، Johnson AB، وآخرون (2003). "Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly". J. Biol. Chem. ج. 278 ع. 8: 5744–9. DOI:10.1074/jbc.M212534200. PMID:12477712.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. Bibcode:2002PNAS...9916899M. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Leonard D، Ajuh P، Lamond AI، Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. ج. 308 ع. 4: 793–801. DOI:10.1016/S0006-291X(03)01486-4. PMID:12927788.
- Gerhard DS، Wagner L، Feingold EA، وآخرون (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. ج. 14 ع. 10B: 2121–7. DOI:10.1101/gr.2596504. PMC:528928. PMID:15489334.
- Klejman MP، Pereira LA، van Zeeburg HJ، وآخرون (2004). "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein". Mol. Cell. Biol. ج. 24 ع. 22: 10072–82. DOI:10.1128/MCB.24.22.10072-10082.2004. PMC:525489. PMID:15509807.
- Lewis BA، Sims RJ، Lane WS، Reinberg D (2005). "Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator". Mol. Cell. ج. 18 ع. 4: 471–81. DOI:10.1016/j.molcel.2005.04.005. PMID:15893730.
- Stelzl U، Worm U، Lalowski M، وآخرون (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. ج. 122 ع. 6: 957–68. DOI:10.1016/j.cell.2005.08.029. PMID:16169070.
- Rual JF، Venkatesan K، Hao T، وآخرون (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. ج. 437 ع. 7062: 1173–8. Bibcode:2005Natur.437.1173R. DOI:10.1038/nature04209. PMID:16189514.
- Assmann EM، Alborghetti MR، Camargo ME، Kobarg J (2006). "FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region". J. Biol. Chem. ج. 281 ع. 15: 9869–81. DOI:10.1074/jbc.M513280200. PMID:16484223.
- Lim J، Hao T، Shaw C، وآخرون (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ج. 125 ع. 4: 801–14. DOI:10.1016/j.cell.2006.03.032. PMID:16713569.
- Albert TK، Grote K، Boeing S، وآخرون (2007). "Global distribution of negative cofactor 2 subunit-alpha on human promoters". Proc. Natl. Acad. Sci. U.S.A. ج. 104 ع. 24: 10000–5. Bibcode:2007PNAS..10410000A. DOI:10.1073/pnas.0703490104. PMC:1891239. PMID:17548813.
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