CLCA2
CLCA2 (Chloride channel accessory 2) هوَ بروتين يُشَفر بواسطة جين CLCA2 في الإنسان.[1][1][2]
الوظيفة
المراجع
- "Entrez Gene: CLCA2 chloride channel, calcium activated, family member 2". مؤرشف من الأصل في 2010-12-05.
- Pawłowski K، Lepistö M، Meinander N، وآخرون (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. ج. 63 ع. 3: 424–39. DOI:10.1002/prot.20887. PMID:16470849.
قراءة متعمقة
- Pauli BU، Abdel-Ghany M، Cheng HC، وآخرون (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. ج. 27 ع. 11: 901–5. DOI:10.1046/j.1440-1681.2000.03358.x. PMID:11071307.
- Gruber AD، Schreur KD، Ji HL، وآخرون (1999). "Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland". Am. J. Physiol. ج. 276 ع. 6 Pt 1: C1261–70. PMID:10362588.
- Agnel M، Vermat T، Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. ج. 455 ع. 3: 295–301. DOI:10.1016/S0014-5793(99)00891-1. PMID:10437792.
- Gruber AD، Pauli BU (1999). "Tumorigenicity of human breast cancer is associated with loss of the Ca2+-activated chloride channel CLCA2". Cancer Res. ج. 59 ع. 21: 5488–91. PMID:10554024.
- Gruber AD، Pauli BU (1999). "Clustering of the human CLCA gene family on the short arm of chromosome 1 (1p22-31)". Genome. ج. 42 ع. 5: 1030–2. DOI:10.1139/gen-42-5-1030. PMID:10584316.
- Liu QH، Williams DA، McManus C، وآخرون (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 9: 4832–7. DOI:10.1073/pnas.090521697. PMC:18318. PMID:10758170.
- Koegel H، Alzheimer C (2001). "Expression and biological significance of Ca2+-activated ion channels in human keratinocytes". FASEB J. ج. 15 ع. 1: 145–154. DOI:10.1096/fj.00-0055com. PMID:11149902.
- Itoh R، Kawamoto S، Miyamoto Y، وآخرون (2001). "Isolation and characterization of a Ca2+-activated chloride channel from human corneal epithelium". Curr. Eye Res. ج. 21 ع. 6: 918–25. DOI:10.1076/ceyr.21.6.918.6983. PMID:11262615.
- Abdel-Ghany M، Cheng HC، Elble RC، Pauli BU (2001). "The breast cancer beta 4 integrin and endothelial human CLCA2 mediate lung metastasis". J. Biol. Chem. ج. 276 ع. 27: 25438–46. DOI:10.1074/jbc.M100478200. PMID:11320086.
- Abdel-Ghany M، Cheng HC، Elble RC، Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. ج. 277 ع. 37: 34391–400. DOI:10.1074/jbc.M205307200. PMID:12110680.
- Strausberg RL، Feingold EA، Grouse LH، وآخرون (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. ج. 99 ع. 26: 16899–903. DOI:10.1073/pnas.242603899. PMC:139241. PMID:12477932.
- Mall M، Gonska T، Thomas J، وآخرون (2003). "Modulation of Ca2+-activated Cl− secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia". Pediatr. Res. ج. 53 ع. 4: 608–18. DOI:10.1203/01.PDR.0000057204.51420.DC. PMID:12612194.
- Abdel-Ghany M، Cheng HC، Elble RC، وآخرون (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. ج. 278 ع. 49: 49406–16. DOI:10.1074/jbc.M309086200. PMID:14512419.
- Connon CJ، Kawasaki S، Yamasaki K، وآخرون (2005). "The quantification of hCLCA2 and colocalisation with integrin beta4 in stratified human epithelia". Acta Histochem. ج. 106 ع. 6: 421–5. DOI:10.1016/j.acthis.2004.08.003. PMID:15707651.
- Connon CJ، Kawasaki S، Liles M، وآخرون (2006). "Gene expression and immunolocalisation of a calcium-activated chloride channel during the stratification of cultivated and developing corneal epithelium". Cell Tissue Res. ج. 323 ع. 1: 177–82. DOI:10.1007/s00441-005-0059-2. PMID:16158324.
- Elble RC، Walia V، Cheng HC، وآخرون (2006). "The putative chloride channel hCLCA2 has a single C-terminal transmembrane segment". J. Biol. Chem. ج. 281 ع. 40: 29448–54. DOI:10.1074/jbc.M605919200. PMID:16873362.
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