CDKN2C
CDKN2C (Cyclin dependent kinase inhibitor 2C) هوَ بروتين يُشَفر بواسطة جين CDKN2C في الإنسان.[1][2][3]
الوظيفة
المراجع
- Blais A، Labrie Y، Pouliot F، Lachance Y، Labrie C (يوليو 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem. Biophys. Res. Commun. ج. 247 ع. 1: 146–53. DOI:10.1006/bbrc.1998.8497. PMID:9636670.
- "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)". مؤرشف من الأصل في 2010-12-05.
- Guan KL، Jenkins CW، Li Y، Nichols MA، Wu X، O'Keefe CL، Matera AG، Xiong Y (يناير 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. ج. 8 ع. 24: 2939–52. DOI:10.1101/gad.8.24.2939. PMID:8001816.
قراءة متعمقة
- Serrano M، Hannon GJ، Beach D (1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4". Nature. ج. 366 ع. 6456: 704–7. DOI:10.1038/366704a0. PMID:8259215.
- Ghosh PK، Anderson J، Cohen N، Takeshita K، Atweh GF، Lebowitz P (1993). "Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia". Oncogene. ج. 8 ع. 10: 2869–72. PMID:8397372.
- Simos G، Maison C، Georgatos SD (1996). "Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope". J. Biol. Chem. ج. 271 ع. 21: 12617–25. DOI:10.1074/jbc.271.21.12617. PMID:8647873.
- Ragione FD، Russo GL، Oliva A، Mercurio C، Mastropietro S، Pietra VD، Zappia V (1996). "Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines". J. Biol. Chem. ج. 271 ع. 27: 15942–9. DOI:10.1074/jbc.271.27.15942. PMID:8663131.
- Lapointe J، Lachance Y، Labrie Y، Labrie C (1996). "A p18 mutant defective in CDK6 binding in human breast cancer cells". Cancer Res. ج. 56 ع. 20: 4586–9. PMID:8840966.
- Venkataramani R، Swaminathan K، Marmorstein R (1998). "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations". Nat. Struct. Biol. ج. 5 ع. 1: 74–81. DOI:10.1038/nsb0198-74. PMID:9437433.
- Fåhraeus R، Laín S، Ball KL، Lane DP (1998). "Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule". Oncogene. ج. 16 ع. 5: 587–96. DOI:10.1038/sj.onc.1201580. PMID:9482104.
- Iolascon A، Giordani L، Moretti A، Basso G، Borriello A، Della Ragione F (1998). "Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma". Hepatology. ج. 27 ع. 4: 989–95. DOI:10.1002/hep.510270414. PMID:9537438.
- Noh SJ، Li Y، Xiong Y، Guan KL (1999). "Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6". Cancer Res. ج. 59 ع. 3: 558–64. PMID:9973200.
- Li J، Byeon IJ، Ericson K، Poi MJ، O'Maille P، Selby T، Tsai MD (1999). "Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A". Biochemistry. ج. 38 ع. 10: 2930–40. DOI:10.1021/bi982286e. PMID:10074345.
- Schreiber M، Muller WJ، Singh G، Graham FL (1999). "Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity". Oncogene. ج. 18 ع. 9: 1663–76. DOI:10.1038/sj.onc.1202466. PMID:10208428.
- Dias Neto E، Correa RG، Verjovski-Almeida S، Briones MR، Nagai MA، da Silva W، Zago MA، Bordin S، Costa FF، Goldman GH، Carvalho AF، Matsukuma A، Baia GS، Simpson DH، Brunstein A، de Oliveira PS، Bucher P، Jongeneel CV، O'Hare MJ، Soares F، Brentani RR، Reis LF، de Souza SJ، Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. ج. 97 ع. 7: 3491–6. DOI:10.1073/pnas.97.7.3491. PMC:16267. PMID:10737800.
- Korshunov A، Golanov A (2002). "Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome". Arch. Pathol. Lab. Med. ج. 126 ع. 1: 42–8. DOI:10.1043/0003-9985(2002)126<0042:IAOPAP>2.0.CO;2. PMID:11800646.
- Blais A، Monté D، Pouliot F، Labrie C (2002). "Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1". J. Biol. Chem. ج. 277 ع. 35: 31679–93. DOI:10.1074/jbc.M204554200. PMID:12077144.
- Arcellana-Panlilio MY، Egeler RM، Ujack E، Magliocco A، Stuart GC، Robbins SM، Coppes MJ (2002). "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors". Genes Chromosomes Cancer. ج. 35 ع. 2: 176–81. DOI:10.1002/gcc.10108. PMID:12203782.
- Komata T، Kanzawa T، Takeuchi H، Germano IM، Schreiber M، Kondo Y، Kondo S (2003). "Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells". Br. J. Cancer. ج. 88 ع. 8: 1277–80. DOI:10.1038/sj.bjc.6600862. PMC:2747579. PMID:12698196.
- Sánchez-Aguilera A، Delgado J، Camacho FI، Sánchez-Beato M، Sánchez L، Montalbán C، Fresno MF، Martín C، Piris MA، García JF (2004). "Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas". Blood. ج. 103 ع. 6: 2351–7. DOI:10.1182/blood-2003-07-2356. PMID:14645011.
بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
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