دينابسولين

دينابسولين
اعتبارات علاجية
معرّفات
CAS	458563-40-1
بوب كيم	9816455
كيم سبايدر	7992205
ChEMBL	CHEMBL124561
بيانات كيميائية
الصيغة الكيميائية	C₁₆H₁₅NO₂[1]
	محددات الإدخال الخطي النصي الجزيئي المبسط
	المعرف الكيميائي الدولي

دينابسولين (بالإنجليزية: Dinapsoline)‏ هو دواءٌ تم تطويره لعلاج داء باركنسون، ويعمل ناهضًا انتقائيًّا كاملًا على مستقبل الدوبامين D₁.[2][3][4][5]

المراجع

dinapsoline (بالإنجليزية), QID:Q278487
Ghosh, Debasis; Snyder, Scott E.; Watts, Val J.; Mailman, Richard B.; Nichols, David E. (1 Jan 1996). "8,9-Dihydroxy-2,3,7,11b-tetrahydro-1 H -naph[1,2,3- de ]isoquinoline: A Potent Full Dopamine D 1 Agonist Containing a Rigid β-Phenyldopamine Pharmacophore". Journal of Medicinal Chemistry (بالإنجليزية). 39 (2): 549–555. DOI:10.1021/jm950707+. ISSN:0022-2623. Archived from the original on 2022-09-01.
Sit, Sing-Yuen; Xie, Kai; Jacutin-Porte, Swanee; Taber, Matthew T.; Gulwadi, Amit G.; Korpinen, Carolyn D.; Burris, Kevin D.; Molski, Thaddeus F.; Ryan, Elaine (1 Aug 2002). "(+)-Dinapsoline: An Efficient Synthesis and Pharmacological Profile of a Novel Dopamine Agonist". Journal of Medicinal Chemistry (بالإنجليزية). 45 (17): 3660–3668. DOI:10.1021/jm0101545. ISSN:0022-2623. Archived from the original on 2022-09-01.
Sit, Sing-Yuen; Xie, Kai; Jacutin-Porte, Swanee; Boy, Kenneth M; Seanz, James; Taber, Matthew T; Gulwadi, Amit G; Korpinen, Carolyn D; Burris, Kevin D (15 Feb 2004). "Synthesis and SAR exploration of dinapsoline analogues". Bioorganic & Medicinal Chemistry (بالإنجليزية). 12 (4): 715–734. DOI:10.1016/j.bmc.2003.11.015. ISSN:0968-0896. Archived from the original on 2022-10-09.
Gleason, Scott D.; Witkin, Jeffrey M. (1 May 2006). "Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine". Psychopharmacology (بالإنجليزية). 186 (1): 25–31. DOI:10.1007/s00213-006-0342-2. ISSN:1432-2072. Archived from the original on 2022-09-01.

بوابة صيدلة
بوابة الكيمياء

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[wikidata-1b49c75d02ab9a15102e8dab00a5b0bab19b3b2a-1] dinapsoline (بالإنجليزية), QID:Q278487

[2] Ghosh, Debasis; Snyder, Scott E.; Watts, Val J.; Mailman, Richard B.; Nichols, David E. (1 Jan 1996). "8,9-Dihydroxy-2,3,7,11b-tetrahydro-1 H -naph[1,2,3- de ]isoquinoline: A Potent Full Dopamine D 1 Agonist Containing a Rigid β-Phenyldopamine Pharmacophore". Journal of Medicinal Chemistry (بالإنجليزية). 39 (2): 549–555. DOI:10.1021/jm950707+. ISSN:0022-2623. Archived from the original on 2022-09-01.

[3] Sit, Sing-Yuen; Xie, Kai; Jacutin-Porte, Swanee; Taber, Matthew T.; Gulwadi, Amit G.; Korpinen, Carolyn D.; Burris, Kevin D.; Molski, Thaddeus F.; Ryan, Elaine (1 Aug 2002). "(+)-Dinapsoline: An Efficient Synthesis and Pharmacological Profile of a Novel Dopamine Agonist". Journal of Medicinal Chemistry (بالإنجليزية). 45 (17): 3660–3668. DOI:10.1021/jm0101545. ISSN:0022-2623. Archived from the original on 2022-09-01.

[4] Sit, Sing-Yuen; Xie, Kai; Jacutin-Porte, Swanee; Boy, Kenneth M; Seanz, James; Taber, Matthew T; Gulwadi, Amit G; Korpinen, Carolyn D; Burris, Kevin D (15 Feb 2004). "Synthesis and SAR exploration of dinapsoline analogues". Bioorganic & Medicinal Chemistry (بالإنجليزية). 12 (4): 715–734. DOI:10.1016/j.bmc.2003.11.015. ISSN:0968-0896. Archived from the original on 2022-10-09.

[5] Gleason, Scott D.; Witkin, Jeffrey M. (1 May 2006). "Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine". Psychopharmacology (بالإنجليزية). 186 (1): 25–31. DOI:10.1007/s00213-006-0342-2. ISSN:1432-2072. Archived from the original on 2022-09-01.